SCHEMBL28083157

SCHEMBL28083157

NCc1c[c]cc(F)c1F

nearest known ligand 0.35

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
LOXL2 Q9Y4K0 1/20 0.35
TAAR1 Q96RJ0 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27714251 0.81 PNMT (0.37) LOXL2
SCHEMBL27754359 0.79 LOXL2 (0.32) LOXL2
SCHEMBL456408 0.78 CTRC (0.30)
SCHEMBL27775235 0.76
SCHEMBL27714209 0.76 PNMT (0.38)
SCHEMBL27754487 0.76 LOXL2 (0.31) LOXL2
SCHEMBL18706050 0.74 TAAR1 (0.31) LOXL2TAAR1
SCHEMBL28112019 0.72
SCHEMBL28112017 0.72
SCHEMBL27776989 0.72

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-106536525-B Compound 葛兰素史密斯克莱知识产权发展有限公司 2019-05-03 CN disclosed
CN-103827116-B As LP-PLA2the 2,3-glyoxalidine of inhibitor also [1,2-c] pyrimidine-5 (1H)-one compound 葛兰素集团有限公司 2016-08-31 CN disclosed