Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Mitotane. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 5/20 | 0.64 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.64 |
| ▸ | LMNA | P02545 | 3/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.64 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.64 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.64 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.64 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.64 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.64 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.64 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.64 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.64 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.64 |
| ▸ | PGR | P06401 | 1/20 | 0.64 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.64 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.64 |
| ▸ | MAPT | P10636 | 1/20 | 0.64 |
| ▸ | CNR1 | P21554 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Mitotane SCHEMBL29360948 | 0.80 | TSHR (1.00) | TSHRHIF1ALMNACYP3A4MAPK1 | |
| Mitotane SCHEMBL4041 | 0.80 | TSHR (1.00) | TSHRHIF1ALMNACYP3A4MAPK1 | |
| Mitotane SCHEMBL2352082 | 0.80 | TSHR (1.00) | TSHRHIF1ALMNACYP3A4MAPK1 | |
| Mitotane SCHEMBL4040 | 0.80 | TSHR (1.00) | TSHRHIF1ALMNACYP3A4MAPK1 | |
| SCHEMBL25502360 | 0.71 | TSHR (0.73) | TSHRHIF1ALMNACYP3A4MAPK1 | |
| Mitotane SCHEMBL8937953 | 0.71 | CNR1 (0.78) | TSHRHIF1ALMNACYP3A4MAPK1 | |
| SCHEMBL13769273 | 0.70 | AOC3 (0.63) | TSHRSLC6A2SLC6A4SLC6A3KDM4E | |
| SCHEMBL1793814 | 0.70 | AOC3 (1.00) | TSHRLMNACYP3A4SLC6A2SLC6A4 | |
| SCHEMBL1164941 | 0.70 | AOC3 (1.00) | TSHRLMNACYP3A4SLC6A2SLC6A4 | |
| Mitotane SCHEMBL8465001 | 0.70 | CNR1 (0.76) | TSHRHIF1ALMNACYP3A4MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103717593-B | Regulate kinase whose compositions and method | 克勒韦谢尔制药公司 | 2016-07-06 | — | — | CN | disclosed |