SCHEMBL28085693

SCHEMBL28085693

CC(=O)Oc1ccc(CN)cc1OCc1ccccc1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTPN1 P18031 1/20 0.54
FFAR4 Q5NUL3 1/20 0.48
MTNR1A P48039 1/20 0.47
MTNR1B P49286 1/20 0.47
CFD P00746 1/20 0.47
PLG P00747 1/20 0.47
PLAU P00749 1/20 0.47
F11 P03951 1/20 0.47
KLKB1 P03952 1/20 0.47
F7 P08709 1/20 0.47
TPSB2 P20231 1/20 0.47
FOLH1 Q04609 1/20 0.47
ALDH1A1 P00352 2/20 0.46
SMPD1 P17405 1/20 0.46
HDAC1 Q13547 1/20 0.46
HDAC8 Q9BY41 1/20 0.46
HDAC6 Q9UBN7 1/20 0.46
MAPT P10636 2/20 0.46
CYP2C9 P11712 1/20 0.46
CYP2C19 P33261 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13326907 0.83 PTGS1 (0.54) CFDALDH1A1
SCHEMBL6726244 0.83 MAOB (0.58) CFDPLGPLAUF11KLKB1
SCHEMBL30821651 0.83 MAOB (0.58) CFDPLGPLAUF11KLKB1
SCHEMBL6702501 0.83 PTPN1 (0.57) PTPN1FFAR4MTNR1AMTNR1BALDH1A1
SCHEMBL8000403 0.83 MAOB (0.57) PTPN1ALDH1A1SMPD1HDAC1HDAC8
SCHEMBL1115032 0.82 PTPN1 (0.61) PTPN1ALDH1A1MAPTCYP2C9CYP2C19
SCHEMBL2776298 0.82 PTPN1 (0.56) PTPN1FFAR4ALDH1A1SMPD1HDAC1
SCHEMBL3722770 0.81 MAPK1 (0.59) F7ALDH1A1SMPD1HDAC1HDAC8
SCHEMBL6199290 0.81 MTNR1A (0.57) PTPN1MTNR1AMTNR1BSMPD1HDAC1
Hydrochloric Acid SCHEMBL9416513 0.80 MAPK1 (0.58) ALDH1A1SMPD1HDAC1HDAC8HDAC6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105849111-B Pyrans and the different cresol derivatives of baynide fibre and metabolic syndrome or treatment of inflammatory diseases pharmaceutical composition 格拉斯如睦株式会社 2018-05-04 CN disclosed
CN-105849111-A Pyranochromenyl phenol derivative, and pharmaceutical composition for treating metabolic syndrome or inflammatory disease 依如睦生物科技株式会社 2016-08-10 CN disclosed