Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 1/20 | 0.56 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.55 |
| ▸ | FFAR4 | Q5NUL3 | 3/20 | 0.55 |
| ▸ | MRGPRX4 | Q96LA9 | 3/20 | 0.52 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | BRD4 | O60885 | 1/20 | 0.50 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1115032 | 0.86 | PTPN1 (0.61) | PTPN1MRGPRX4NPC1BRD4L3MBTL1 | |
| SCHEMBL28085586 | 0.86 | AKR1C3 (0.54) | FFAR1FFAR4MRGPRX4AKR1C3NPC1 | |
| SCHEMBL28238348 | 0.86 | FFAR1 (0.55) | FFAR1FFAR4MRGPRX4AKR1C3NPC1 | |
| SCHEMBL8000403 | 0.84 | MAOB (0.57) | PTPN1L3MBTL1ALDH1A1SMPD1HDAC1 | |
| SCHEMBL6702501 | 0.84 | PTPN1 (0.57) | PTPN1FFAR4BRD4L3MBTL1ALDH1A1 | |
| SCHEMBL6199290 | 0.82 | MTNR1A (0.57) | PTPN1MRGPRX4AKR1C3NPC1LRRK2 | |
| SCHEMBL28085693 | 0.82 | PTPN1 (0.54) | PTPN1FFAR1FFAR4BRD4L3MBTL1 | |
| SCHEMBL29707531 | 0.81 | LRRK2 (0.60) | MRGPRX4NPC1BRD4LRRK2L3MBTL1 | |
| SCHEMBL1041517 | 0.81 | MAOB (0.61) | FFAR1FFAR4NPC1BRD4LRRK2 | |
| SCHEMBL30956730 | 0.81 | MAOB (0.61) | FFAR1FFAR4NPC1BRD4LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102557971-B | Substituted acids for the treatment of respiratory diseases | ASTRAZENECA AB | 2015-06-17 | — | — | CN | disclosed |
| CN-102557971-A | Substituted acids for the treatment of respiratory diseases | ASTRAZENECA AB | 2012-07-11 | — | — | CN | disclosed |
| CN-101014564-B | Substituted acids for the treatment of respiratory diseases | ASTRAZENECA AB | 2012-05-09 | — | — | CN | disclosed |
| CN-102046618-A | Hydroxyquinoxalinecarboxamide derivative | DAIICHI SANKYO CO LTD | 2011-05-04 | — | — | CN | disclosed |
| US-20110053933-A1 | HYDROXYQUINOXALINECARBOXAMIDE DERIVATIVE | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2011-03-03 | — | — | US | disclosed |
| EP-2258697-A1 | HYDROXYQUINOXALINECARBOXAMIDE DERIVATIVE | Daiichi Sankyo Company, Limited (JP) | 2010-12-08 | — | — | EP | disclosed |
| CN-101014564-A | Substituted acids for the treatment of respiratory diseases | ASTRAZENECA AB (SE) | 2007-08-08 | — | — | CN | disclosed |
| EP-1765768-A1 | SUBSTITUTED ACIDS FOR THE TREATMENT OF RESPIRATORY DISEASES | AstraZeneca AB (SE) | 2007-03-28 | — | — | EP | disclosed |
| WO-2006005909-A1 | SUBSTITUTED ACIDS FOR THE TREATMENT OF RESPIRATORY DISEASES | ASTRAZENECA AB (SE) | 2006-01-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110053933-A1 | HYDROXYQUINOXALINECARBOXAMIDE DERIVATIVE | F12, F2, C3AR1 | PTPN1 2343/4885FFAR1 2059/4885FFAR4 2327/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.