Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bezitramide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 known ✓ | Q99720 | 10/20 | 0.52 |
| ▸ | OPRM1 | P35372 | 7/20 | 0.52 |
| ▸ | OPRD1 | P41143 | 5/20 | 0.52 |
| ▸ | OPRK1 | P41145 | 5/20 | 0.52 |
| ▸ | TMEM97 | Q5BJF2 | 3/20 | 0.52 |
| ▸ | EBP | Q15125 | 2/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bezitramide SCHEMBL25733 | 0.79 | OPRM1 (0.55) | OPRM1NPSR1 | |
| Bezitramide SCHEMBL29387545 | 0.79 | OPRM1 (0.55) | OPRM1NPSR1 | |
| Pentazocine SCHEMBL29801598 | 0.73 | SIGMAR1 (0.98) | SIGMAR1OPRM1OPRD1OPRK1TMEM97 | |
| Pentazocine SCHEMBL31568850 | 0.72 | OPRM1 (0.81) | SIGMAR1OPRM1OPRD1OPRK1TMEM97 | |
| (+)-Pentazocine SCHEMBL680675 | 0.72 | SIGMAR1 (1.00) | SIGMAR1OPRM1OPRD1OPRK1TMEM97 | |
| (+)-Pentazocine SCHEMBL4376337 | 0.72 | SIGMAR1 (1.00) | SIGMAR1OPRM1OPRD1OPRK1TMEM97 | |
| (+)-Pentazocine SCHEMBL2492 | 0.72 | SIGMAR1 (1.00) | SIGMAR1OPRM1OPRD1OPRK1TMEM97 | |
| (+)-Pentazocine SCHEMBL18672553 | 0.72 | SIGMAR1 (1.00) | SIGMAR1OPRM1OPRD1OPRK1TMEM97 | |
| (+)-Pentazocine SCHEMBL22865258 | 0.72 | SIGMAR1 (1.00) | SIGMAR1OPRM1OPRD1OPRK1TMEM97 | |
| Pentazocine SCHEMBL2493 | 0.72 | SIGMAR1 (1.00) | SIGMAR1OPRM1OPRD1OPRK1TMEM97 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103717597-B | Heterocyclic compounds as kinase inhibitors | 原真股份有限公司 | 2017-07-04 | — | — | CN | disclosed |
| CN-103492389-B | Pyrazolo [4,3-d] pyrimidine as inhibitors of kinases | 原真股份有限公司 | 2016-09-14 | — | — | CN | disclosed |