Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Floxacillin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB11 | O95342 | 3/20 | 0.92 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.92 |
| ▸ | LMNA | P02545 | 3/20 | 0.78 |
| ▸ | HPGD | P15428 | 3/20 | 0.71 |
| ▸ | MEN1 | O00255 | 2/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.71 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.70 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.70 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.70 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.52 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | PPARG | P37231 | 1/20 | 0.51 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Floxacillin SCHEMBL1458003 | 0.96 | ABCB11 (1.00) | ABCB11CYP1A2LMNAHPGDMEN1 | |
| Floxacillin SCHEMBL14126462 | 0.96 | ABCB11 (1.00) | ABCB11CYP1A2LMNAHPGDMEN1 | |
| Floxacillin SCHEMBL3823 | 0.96 | ABCB11 (1.00) | ABCB11CYP1A2LMNAHPGDMEN1 | |
| Floxacillin SCHEMBL22651560 | 0.96 | ABCB11 (1.00) | ABCB11CYP1A2LMNAHPGDMEN1 | |
| Floxacillin SCHEMBL855083 | 0.95 | ABCB11 (0.98) | ABCB11CYP1A2LMNAHPGDMEN1 | |
| Dicloxacillin SCHEMBL21643600 | 0.95 | ABCB11 (0.98) | ABCB11CYP1A2LMNAHPGDMEN1 | |
| Floxacillin SCHEMBL1442294 | 0.95 | ABCB11 (0.98) | ABCB11CYP1A2LMNAHPGDMEN1 | |
| Floxacillin SCHEMBL2636814 | 0.94 | ABCB11 (0.97) | ABCB11CYP1A2LMNAHPGDMEN1 | |
| Dicloxacillin SCHEMBL11407710 | 0.91 | ABCB11 (1.00) | ABCB11CYP1A2LMNAHPGDMEN1 | |
| Dicloxacillin SCHEMBL11407708 | 0.91 | ABCB11 (1.00) | ABCB11CYP1A2LMNAHPGDMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103717597-B | Heterocyclic compounds as kinase inhibitors | 原真股份有限公司 | 2017-07-04 | — | — | CN | disclosed |
| CN-103492389-B | Pyrazolo [4,3-d] pyrimidine as inhibitors of kinases | 原真股份有限公司 | 2016-09-14 | — | — | CN | disclosed |