Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Floxacillin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB11 | O95342 | 3/20 | 0.98 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.98 |
| ▸ | LMNA | P02545 | 3/20 | 0.82 |
| ▸ | HPGD | P15428 | 4/20 | 0.75 |
| ▸ | MEN1 | O00255 | 2/20 | 0.75 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.75 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.75 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.74 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.62 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.55 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Floxacillin SCHEMBL2636814 | 0.99 | ABCB11 (0.97) | ABCB11CYP1A2LMNAHPGDMEN1 | |
| Floxacillin SCHEMBL3823 | 0.99 | ABCB11 (1.00) | ABCB11CYP1A2LMNAHPGDMEN1 | |
| Floxacillin SCHEMBL22651560 | 0.99 | ABCB11 (1.00) | ABCB11CYP1A2LMNAHPGDMEN1 | |
| Floxacillin SCHEMBL14126462 | 0.99 | ABCB11 (1.00) | ABCB11CYP1A2LMNAHPGDMEN1 | |
| Floxacillin SCHEMBL1458003 | 0.99 | ABCB11 (1.00) | ABCB11CYP1A2LMNAHPGDMEN1 | |
| Dicloxacillin SCHEMBL21643600 | 0.98 | ABCB11 (0.98) | ABCB11CYP1A2LMNAHPGDMEN1 | |
| Floxacillin SCHEMBL1442294 | 0.98 | ABCB11 (0.98) | ABCB11CYP1A2LMNAHPGDMEN1 | |
| Floxacillin SCHEMBL28086634 | 0.95 | ABCB11 (0.92) | ABCB11CYP1A2LMNAHPGDMEN1 | |
| Dicloxacillin SCHEMBL41517 | 0.95 | ABCB11 (0.98) | ABCB11CYP1A2LMNAHPGDMEN1 | |
| Dicloxacillin SCHEMBL28536434 | 0.95 | ABCB11 (0.98) | ABCB11CYP1A2LMNAHPGDMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 736 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4566590-A1 | TASTE-MASKING MICROSPHERE, PREPARATION PROCESS THEREFOR, AND USE THEREOF | Harbin Kanon Pharmaceutical Co., Ltd (CN) | 2025-06-11 | — | — | EP | claimed |
| US-12274830-B2 | Nitric oxide inhalation therapy for infants with bronchiolitis | BEYOND AIR LTD (IL) | 2025-04-15 | — | — | US | claimed |
| CN-221933766-U | Uniform mixing device for amoxicillin sodium and flucloxacillin sodium | 山西振东泰盛制药有限公司 | 2024-11-01 | — | — | CN | claimed |
| CN-117503707-B | Taste-masking microsphere and preparation process and application thereof | 哈尔滨市康隆药业有限责任公司 | 2024-08-23 | — | — | CN | claimed |
| US-20240173512-A1 | METHODS FOR POTENTIATING ANTIMICROBIAL AGENTS | STREETERVILLE CAPITAL, LLC | 2024-05-30 | — | — | US | claimed |
| WO-2024027794-A1 | TASTE-MASKING MICROSPHERE, PREPARATION PROCESS THEREFOR, AND USE THEREOF | 哈尔滨市康隆药业有限责任公司 | 2024-02-08 | — | — | WO | claimed |
| US-11890421-B2 | Methods for potentiating antimicrobial agents | BEYOND AIR LTD (IL) | 2024-02-06 | — | — | US | claimed |
| CN-117503707-A | Taste-masking microsphere and preparation process and application thereof | 哈尔滨市康隆药业有限责任公司 | 2024-02-06 | — | — | CN | claimed |
| US-20230346879-A1 | COMPOSITIONS AND METHODS FOR COMBINATORIAL DRUG DISCOVERY IN NANOLITER DROPLETS | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 2023-11-02 | — | — | US | claimed |
| CN-114163360-B | Synthesis and taste masking application of water-soluble biphenyl aromatic hydrocarbon | 天津师范大学 | 2023-03-24 | — | — | CN | claimed |
| US-6500459-B1 | PHARMACEUTICAL COMPOSITION FOR CONTROLLED ONSET AND SUSTAINED RELEASE OF ACTIVE INGREDIENT COMPRISING CORE COMPRISING ACTIVE INGREDIENT, HYDROPHILIC CARRIER AND HYDRODYNAMIC DIFFUSION ENHANCER WITH FUNCTIONAL COATING MEMBRANE SURROUNDING CORE | CHHABRA HARINDERPAL (US) | 2002-12-31 | — | — | US | claimed |
| WO-2002098464-A2 | LIQUID POLYMER COMPOSITION FOR PREVENTION AND TREATMENT OF THE ORAL CAVITY DISEASES | ITALMED S.N.C. DI GALLI G. & PACINI G. (IT) | 2002-12-12 | — | — | WO | claimed |
| EP-1262172-A1 | Liquid polymer composition for prevention and treatment of the oral cavity diseases | Italmed S.N.C. Di Galli G. & Pacini G. (IT) | 2002-12-04 | — | — | EP | claimed |
| US-5811547-A | Method for inducing crystalline state transition in medicinal substance | NIPPON SHINYAJU CO., LTD. (JP) | 1998-09-22 | — | — | US | claimed |
| US-4952402-A | EDIBLE TASTE-MASKED DRUGS; MICROMATRIX ACTIVE MATERIAL COATED WITH NONTOXIC POLYMER; LIQUIDS; TABLETS | ELAN CORPORATION, P.L.C. (IE) | 1990-08-28 | — | — | US | claimed |
| US-4369172-A | Prolonged release therapeutic compositions based on hydroxypropylmethylcellulose | FOREST LABORATORIES INC. (US) | 1983-01-18 | — | — | US | claimed |
| EP-0010904-B1 | INTRAMAMMARY COMPOSITIONS AND PROCESS FOR THEIR PREPARATION | BEECHAM GROUP PLC (GB) | 1982-05-05 | — | — | EP | claimed |
| US-4282202-A | Intramammary compositions | BEECHAM GROUP LIMITED (GB) | 1981-08-04 | — | — | US | claimed |
| EP-0010904-A2 | Intramammary compositions and process for their preparation | BEECHAM GROUP PLC (GB) | 1980-05-14 | — | — | EP | claimed |
| EP-0008178-A2 | Powder, process for its preparation, container holding it, and syrup comprising the powder reconstituted with water | BEECHAM GROUP PLC (GB) | 1980-02-20 | — | — | EP | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230346879-A1 | COMPOSITIONS AND METHODS FOR COMBINATORIAL DRUG DISCOVERY IN NANOLITER DROPLETS | RAB5IF, CLTB, TBK1 | ABCB11 2506/4885CYP1A2 4441/4885LMNA 3886/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.