Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Floxacillin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB11 | O95342 | 3/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 1/20 | 1.00 |
| ▸ | LMNA | P02545 | 3/20 | 0.84 |
| ▸ | HPGD | P15428 | 4/20 | 0.76 |
| ▸ | MEN1 | O00255 | 2/20 | 0.76 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.76 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.76 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.75 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.75 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.63 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.56 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Floxacillin SCHEMBL3823 | 1.00 | ABCB11 (1.00) | ABCB11CYP1A2LMNAHPGDMEN1 | |
| Floxacillin SCHEMBL14126462 | 1.00 | ABCB11 (1.00) | ABCB11CYP1A2LMNAHPGDMEN1 | |
| Floxacillin SCHEMBL1458003 | 1.00 | ABCB11 (1.00) | ABCB11CYP1A2LMNAHPGDMEN1 | |
| Floxacillin SCHEMBL1442294 | 0.99 | ABCB11 (0.98) | ABCB11CYP1A2LMNAHPGDMEN1 | |
| Dicloxacillin SCHEMBL21643600 | 0.99 | ABCB11 (0.98) | ABCB11CYP1A2LMNAHPGDMEN1 | |
| Floxacillin SCHEMBL855083 | 0.99 | ABCB11 (0.98) | ABCB11CYP1A2LMNAHPGDMEN1 | |
| Floxacillin SCHEMBL2636814 | 0.98 | ABCB11 (0.97) | ABCB11CYP1A2LMNAHPGDMEN1 | |
| Floxacillin SCHEMBL28086634 | 0.96 | ABCB11 (0.92) | ABCB11CYP1A2LMNAHPGDMEN1 | |
| Dicloxacillin SCHEMBL11407708 | 0.95 | ABCB11 (1.00) | ABCB11CYP1A2LMNAHPGDMEN1 | |
| Dicloxacillin SCHEMBL11407710 | 0.95 | ABCB11 (1.00) | ABCB11CYP1A2LMNAHPGDMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230346879-A1 | COMPOSITIONS AND METHODS FOR COMBINATORIAL DRUG DISCOVERY IN NANOLITER DROPLETS | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 2023-11-02 | — | — | US | disclosed |
| US-20230346879-A1 | COMPOSITIONS AND METHODS FOR COMBINATORIAL DRUG DISCOVERY IN NANOLITER DROPLETS | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 2023-11-02 | — | — | US | disclosed |
| US-11564970-B2 | Compositions and methods for combinatorial drug discovery in nanoliter droplets | THE BROAD INSTITUTE, INC. (US) | 2023-01-31 | — | — | US | disclosed |
| US-20200353033-A1 | COMPOSITIONS AND METHODS FOR COMBINATORIAL DRUG DISCOVERY IN NANOLITER DROPLETS | THE BROAD INSTITUTE, INC. (US) | 2020-11-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230346879-A1 | COMPOSITIONS AND METHODS FOR COMBINATORIAL DRUG DISCOVERY IN NANOLITER DROPLETS | RAB5IF, CLTB, TBK1 | ABCB11 2506/4885CYP1A2 4441/4885LMNA 3886/4885 |
| US-20200353033-A1 | COMPOSITIONS AND METHODS FOR COMBINATORIAL DRUG DISCOVERY IN NANOLITER DROPLETS | RAB5IF, CLTB, TBK1 | ABCB11 2506/4885CYP1A2 4441/4885LMNA 3886/4885 |
| US-11564970-B2 | Compositions and methods for combinatorial drug discovery in nanoliter droplets | RAB5IF, LIPA, CLTB | ABCB11 2534/4885CYP1A2 4134/4885LMNA 3616/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.