Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxyphenbutazone Anhydrous. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 known ✓ | P23219 | 2/20 | 0.77 |
| ▸ | LMNA | P02545 | 3/20 | 0.77 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.77 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.77 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.77 |
| ▸ | RAB9A | P51151 | 2/20 | 0.77 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.77 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.77 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.77 |
| ▸ | TP53 | P04637 | 1/20 | 0.77 |
| ▸ | MAPT | P10636 | 1/20 | 0.77 |
| ▸ | HPGD | P15428 | 1/20 | 0.77 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.77 |
| ▸ | CES2 | O00748 | 10/20 | 0.43 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.37 |
| ▸ | LOX | P28300 | 1/20 | 0.36 |
| ▸ | LOXL3 | P58215 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phenylbutazone SCHEMBL28843709 | 0.95 | ALDH1A1 (0.68) | LMNAALDH1A1CYP3A4PTGS1MAPK1 | |
| Mofebutazone SCHEMBL27513530 | 0.89 | ALDH1A1 (0.57) | LMNAALDH1A1CYP3A4PTGS1MAPK1 | |
| Oxyphenbutazone Anhydrous SCHEMBL11337449 | 0.88 | LMNA (1.00) | LMNAALDH1A1CYP3A4PTGS1MAPK1 | |
| Oxyphenbutazone Anhydrous SCHEMBL25856 | 0.88 | LMNA (1.00) | LMNAALDH1A1CYP3A4PTGS1MAPK1 | |
| Oxyphenbutazone Anhydrous SCHEMBL25857 | 0.88 | LMNA (1.00) | LMNAALDH1A1CYP3A4PTGS1MAPK1 | |
| Oxyphenbutazone Anhydrous SCHEMBL5316370 | 0.88 | LMNA (1.00) | LMNAALDH1A1CYP3A4PTGS1MAPK1 | |
| Oxyphenbutazone Anhydrous SCHEMBL3182776 | 0.87 | LMNA (0.97) | LMNAALDH1A1CYP3A4PTGS1MAPK1 | |
| Oxyphenbutazone Anhydrous SCHEMBL2525061 | 0.87 | LMNA (0.97) | LMNAALDH1A1CYP3A4PTGS1MAPK1 | |
| Oxyphenbutazone Anhydrous SCHEMBL25854 | 0.87 | LMNA (0.97) | LMNAALDH1A1CYP3A4PTGS1MAPK1 | |
| Oxyphenbutazone Anhydrous SCHEMBL1263248 | 0.87 | LMNA (0.97) | LMNAALDH1A1CYP3A4PTGS1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103717597-B | Heterocyclic compounds as kinase inhibitors | 原真股份有限公司 | 2017-07-04 | — | — | CN | disclosed |
| CN-103492389-B | Pyrazolo [4,3-d] pyrimidine as inhibitors of kinases | 原真股份有限公司 | 2016-09-14 | — | — | CN | disclosed |