Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 known ✓ | P03372 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA4 | P22748 | 1/20 | 0.39 |
| ▸ | CA5A | P35218 | 1/20 | 0.39 |
| ▸ | CFTR | P13569 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | ALPG | P10696 | 1/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
| ▸ | NPY1R | P25929 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | NPY2R | P49146 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27433007 | 0.86 | CA2 (0.50) | CA2CA4CA5ACFTRGAA | |
| Benzene SCHEMBL28274900 | 0.83 | CA2 (0.52) | CA2CA4CA5ACFTRGAA | |
| SCHEMBL140712 | 0.83 | CA2 (0.52) | CA2CA4CA5ACFTRGAA | |
| SCHEMBL28809780 | 0.83 | CA2 (0.52) | CA2CA4CA5ACFTRGAA | |
| Triphenylphosphine Oxide SCHEMBL7110277 | 0.77 | LMNA (0.47) | CA2CA4CA5ACFTRSIGMAR1 | |
| Carbon Tetrachloride SCHEMBL28663038 | 0.77 | CA2 (0.46) | CA2CA4CA5ACFTRGAA | |
| Chloroform SCHEMBL28441982 | 0.77 | CA2 (0.46) | CA2CA4CA5ACFTRGAA | |
| Phenylphosphonic Acid SCHEMBL29009405 | 0.76 | CA2 (0.73) | CA2CA4CA5ACFTRSIGMAR1 | |
| Phenylphosphonic Acid SCHEMBL29788868 | 0.73 | CA2 (0.76) | CA2CA4CA5ACFTRGAA | |
| Urea SCHEMBL11426798 | 0.73 | CA2 (0.48) | CA2CA4CA5ACFTRGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105924625-B | A kind of water white transparency Halogenless fire retarded epoxy resin of low-temperature curable and preparation method thereof | 长春工业大学 | 2018-08-24 | — | — | CN | disclosed |
| CN-105924626-B | A kind of halogen-free flameproof curing agent of liquid water white transparency epoxy resin and preparation method thereof | 长春工业大学 | 2018-06-19 | — | — | CN | disclosed |
| CN-105924625-A | Colorless, transparent, halogen-free and flame-retardant epoxy resin capable of being cured at low temperature and preparation method thereof | 长春工业大学 | 2016-09-07 | — | — | CN | disclosed |
| CN-105924626-A | Liquid colorless and transparent epoxy resin halogen-free flame retardant curing agent and preparation method thereof | 长春工业大学 | 2016-09-07 | — | — | CN | disclosed |