Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS | O95271 | 1/20 | 0.49 |
| ▸ | NMUR2 | Q9GZQ4 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.43 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28212030 | 0.85 | MAPK14 (0.55) | TNKSSMN1; SMN2MAPK14MAPK1MEN1 | |
| SCHEMBL28088013 | 0.85 | KMT2A (0.53) | TNKSNMUR2SMN1; SMN2CYP19A1MAPK14 | |
| SCHEMBL28352881 | 0.82 | TNKS (0.49) | TNKSNMUR2SMN1; SMN2CYP19A1CYP11B1 | |
| SCHEMBL28088011 | 0.82 | LMNA (0.58) | TNKSSMN1; SMN2MAPK14MAOBMAPK1 | |
| SCHEMBL28088260 | 0.79 | CYP3A4 (0.54) | SMN1; SMN2MAPK14MAPK1MEN1CYP3A4 | |
| SCHEMBL28088009 | 0.78 | ABCG2 (0.64) | TNKSSMN1; SMN2MAOBMEN1CYP3A4 | |
| SCHEMBL28961144 | 0.77 | DDR2 (0.54) | TNKSNMUR2SMN1; SMN2CYP19A1CYP11B1 | |
| SCHEMBL28555552 | 0.77 | CYP3A4 (0.51) | TNKSNMUR2SMN1; SMN2CYP19A1CYP11B1 | |
| SCHEMBL6825720 | 0.75 | MAPK14 (0.52) | TNKSSMN1; SMN2MAPK14MAPK1MEN1 | |
| SCHEMBL28263406 | 0.74 | CNR2 (0.43) | SMN1; SMN2MAPK14MAPK1MEN1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105837539-A | Method for substituting 2-site aryl for 3-site fluoro of benzofuran ring | 复旦大学 | 2016-08-10 | — | — | CN | disclosed |