Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.37 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 4/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.32 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.32 |
| ▸ | DAO | P14920 | 1/20 | 0.32 |
| ▸ | KDM5A | P29375 | 1/20 | 0.32 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2438107 | 0.75 | GABRP (0.46) | SMN1; SMN2ALDH1A1ALOX15CYP1A2KDM4E | |
| SCHEMBL8629182 | 0.71 | SMN1; SMN2 (0.42) | SMN1; SMN2LMNAALDH1A1KEAP1NFE2L2 | |
| SCHEMBL400674 | 0.67 | EGFR (0.54) | SMN1; SMN2LMNAALDH1A1KEAP1NFE2L2 | |
| SCHEMBL8487622 | 0.66 | ALDH1A1 (0.47) | LMNAALDH1A1KEAP1TSHRALOX15 | |
| SCHEMBL16278616 | 0.66 | NR4A1 (0.44) | SMN1; SMN2LMNAALDH1A1TSHRALOX15 | |
| Hydrochloric Acid SCHEMBL921288 | 0.65 | EGFR (0.53) | SMN1; SMN2LMNAALDH1A1KEAP1NFE2L2 | |
| SCHEMBL7444717 | 0.65 | ALDH1A1 (0.37) | SMN1; SMN2LMNAALDH1A1TSHRTP53 | |
| SCHEMBL29378242 | 0.65 | SMN1; SMN2 (0.50) | SMN1; SMN2LMNAALDH1A1KEAP1NFE2L2 | |
| SCHEMBL56617 | 0.65 | SMN1; SMN2 (0.50) | SMN1; SMN2LMNAALDH1A1KEAP1NFE2L2 | |
| SCHEMBL750508 | 0.64 | ALDH1A1 (0.50) | SMN1; SMN2LMNAALDH1A1TSHRTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103608332-B | Pyridine-2-amides useful as CB2 agonists | 霍夫曼-拉罗奇有限公司 | 2016-09-28 | — | — | CN | disclosed |