SCHEMBL28089573

SCHEMBL28089573

Cc1ccc(C(C)(C)C)c(-c2ccc(O)cc2)c1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOB P27338 1/20 0.43
ACHE P22303 1/20 0.43
TYR P14679 3/20 0.42
ALDH1A1 P00352 3/20 0.42
LMNA P02545 2/20 0.42
CYP2C9 P11712 2/20 0.42
NR1I2 O75469 1/20 0.42
MIF P14174 1/20 0.42
ALOX15 P16050 1/20 0.42
HTT P42858 1/20 0.42
NFE2L2 Q16236 1/20 0.42
HSD17B10 Q99714 1/20 0.42
ESRRA P11474 1/20 0.41
CA2 P00918 2/20 0.41
POLB P06746 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.41
MAPK1 P28482 1/20 0.39
MAP2K4 P45985 1/20 0.39
MAPKAPK2 P49137 1/20 0.39
MAPKAPK3 Q16644 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28136642 0.85 TYR (0.45) MAOBACHETYRALDH1A1LMNA
SCHEMBL2954728 0.82 MAOB (0.41) MAOBACHETYRLMNAMIF
SCHEMBL27432524 0.82 HSD17B10 (0.50) TYRALDH1A1LMNACYP2C9NR1I2
SCHEMBL28257273 0.81 LMNA (0.54) TYRALDH1A1LMNACYP2C9NR1I2
SCHEMBL12597779 0.79 APP (0.41) KIF11TSHR
SCHEMBL18648263 0.78 ALDH1A1 (0.55) TYRALDH1A1LMNACYP2C9NR1I2
SCHEMBL14363399 0.76 BACE1 (0.51) MAOBACHEALDH1A1LMNAALOX15
SCHEMBL29637921 0.76 ESRRA (0.61) MAOBACHEALDH1A1ESRRAMAPK1
SCHEMBL6897471 0.76 ESRRA (0.61) MAOBACHEALDH1A1ESRRAMAPK1
SCHEMBL7855632 0.75 HSD17B10 (0.57) TYRALDH1A1LMNACYP2C9NR1I2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110114448-B Lubricating composition with alkylated naphthylamines 路博润公司 2022-03-04 CN disclosed
CN-113403035-A Heat transfer compositions, methods, and systems 霍尼韦尔国际公司 2021-09-17 CN disclosed
CN-107849307-B Additive mixture 巴斯夫欧洲公司 2020-12-01 CN disclosed
CN-110105687-A Weather-proof aerial cable and preparation method thereof is blended in protective cover material, modified polyvinyl chloride alkenyl 上海新益电力线路器材有限公司 2019-08-09 CN disclosed
CN-107108773-B Photocurable resin composition, cured product thereof, and method for producing cured product 三键有限公司 2019-05-17 CN disclosed
CN-205836293-U A kind of antioxidation stamping systems 扬州市祥华新材料科技有限公司 2016-12-28 CN disclosed
CN-105867069-A Negative-type photosensitive resin composition, photocuring pattern formed by using the same and image display device 东友精细化工有限公司 2016-08-17 CN disclosed