Fluocinonide

SCHEMBL28089918

CC(=O)OCC(=O)[C@@]12OC(C)(C)O[C@@H]1C[C@H]1[C@@H]3C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@@]12C.CC1(C)O[C@@H]2C[C@H]3[C@@H]4C[C@H](F)C5=CC(=O)C=C[C@]5(C)[C@@]4(F)[C@@H](O)C[C@]3(C)[C@]2(C(=O)CO)O1

nearest known ligand 0.94

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

NR3C1

The experimentally established mechanism targets of Fluocinonide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

	gene	UniProt	supporting neighbours	confidence
▸	NR3C1 known ✓	P04150	10/20	0.94

▸	HIF1A	Q16665	7/20	0.94

▸	LMNA	P02545	6/20	0.94

▸	PGR	P06401	6/20	0.94

▸	AR	P10275	3/20	0.94

▸	ALDH1A1	P00352	2/20	0.94

▸	MEN1	O00255	1/20	0.94

▸	KMT2A	Q03164	1/20	0.94

▸	CYP3A4	P08684	4/20	0.87

▸	MAPT	P10636	2/20	0.87

▸	HSD17B10	Q99714	1/20	0.87

▸	TDP1	Q9NUW8	1/20	0.87

▸	KDM4E	B2RXH2	1/20	0.87

▸	MAPK1	P28482	1/20	0.87

▸	NR1I2	O75469	1/20	0.65

▸	SMN1; SMN2	Q16637	1/20	0.63

▸	CYP1A2	P05177	1/20	0.63

▸	ESR1	P03372	1/20	0.63

▸	CNR1	P21554	1/20	0.63

▸	KCNH2	Q12809	1/20	0.63

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
Fluocinonide SCHEMBL9338347	0.97	HIF1A (1.00)	NR3C1HIF1ALMNAPGRAR
Fluocinonide SCHEMBL13072509	0.97	HIF1A (1.00)	NR3C1HIF1ALMNAPGRAR
Fluocinonide SCHEMBL2962841	0.97	HIF1A (1.00)	NR3C1HIF1ALMNAPGRAR
Fluocinonide SCHEMBL2800723	0.97	HIF1A (1.00)	NR3C1HIF1ALMNAPGRAR
Fluocinonide SCHEMBL13072779	0.97	HIF1A (1.00)	NR3C1HIF1ALMNAPGRAR
Fluocinonide SCHEMBL13026147	0.97	HIF1A (1.00)	NR3C1HIF1ALMNAPGRAR
Fluocinonide SCHEMBL4262	0.97	HIF1A (1.00)	NR3C1HIF1ALMNAPGRAR
Fluocinonide SCHEMBL13568069	0.97	HIF1A (1.00)	NR3C1HIF1ALMNAPGRAR
Fluocinonide SCHEMBL2895156	0.96	HIF1A (0.98)	NR3C1HIF1ALMNAPGRAR
Fluocinonide SCHEMBL28118986	0.96	NR3C1 (0.98)	NR3C1HIF1ALMNAPGRAR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
CN-106278999-B	S1P regulator	比奥根MA公司	2019-10-25	—	—	CN	disclosed
CN-106278999-A	S1p regulator	比奥根MA公司	2017-01-04	—	—	CN	disclosed
CN-103533835-B	S1P modulators	比奥根MA公司	2016-08-24	—	—	CN	disclosed