Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.55 |
| ▸ | MEN1 | O00255 | 3/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | TTR | P02766 | 2/20 | 0.55 |
| ▸ | PPOX | P50336 | 1/20 | 0.55 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.51 |
| ▸ | F10 | P00742 | 1/20 | 0.50 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.47 |
| ▸ | AKR1C2 | P52895 | 3/20 | 0.47 |
| ▸ | AKR1C1 | Q04828 | 2/20 | 0.47 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.47 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.47 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.47 |
| ▸ | SLC25A1 | P53007 | 1/20 | 0.46 |
| ▸ | MERTK | Q12866 | 1/20 | 0.45 |
| ▸ | ALB | P02768 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10784715 | 0.88 | TDP1 (0.58) | TDP1MEN1KMT2ATTRPPOX | |
| SCHEMBL16792618 | 0.85 | SLC6A4 (0.51) | TDP1MEN1KMT2ATTRPPOX | |
| SCHEMBL16814217 | 0.85 | TDP1 (0.50) | TDP1MEN1KMT2ATTRPPOX | |
| SCHEMBL80744 | 0.84 | TDP1 (0.67) | TDP1MEN1KMT2ATTRPPOX | |
| SCHEMBL706437 | 0.84 | HPSE (0.51) | TDP1MEN1KMT2ATTRPPOX | |
| SCHEMBL8740792 | 0.82 | HPGD (0.51) | TDP1MEN1KMT2AHPSESLC25A1 | |
| SCHEMBL4739689 | 0.82 | KMO (0.56) | ALDH1A1 | |
| SCHEMBL30775030 | 0.82 | KMO (0.56) | ALDH1A1 | |
| SCHEMBL10502108 | 0.80 | MEN1 (0.54) | MEN1KMT2AHPSEF10SLC25A1 | |
| SCHEMBL10663721 | 0.80 | TDP1 (0.69) | TDP1MEN1KMT2ATTRPPOX |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105793252-A | Inhibitors of bruton's tyrosine kinase | 豪夫迈·罗氏有限公司 | 2016-07-20 | — | — | CN | disclosed |