Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Propylene Glycol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.53 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 6/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CCR7 | P32248 | 1/20 | 0.31 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Propylene Glycol SCHEMBL10765776 | 0.97 | HSD17B10 (0.64) | HSD17B10TDP1USP2TSHRMEN1 | |
| Propylene Glycol SCHEMBL56047 | 0.97 | HSD17B10 (0.64) | HSD17B10TDP1USP2TSHRMEN1 | |
| Propylene Glycol SCHEMBL10613711 | 0.95 | HSD17B10 (0.61) | HSD17B10TDP1USP2TSHRMEN1 | |
| Propylene Glycol SCHEMBL15353567 | 0.92 | HSD17B10 (0.58) | HSD17B10TDP1USP2TSHRMEN1 | |
| Propylene Glycol SCHEMBL3630707 | 0.90 | HSD17B10 (0.56) | HSD17B10TDP1USP2TSHRMEN1 | |
| Propylene Glycol SCHEMBL10406157 | 0.88 | TSHR (0.56) | HSD17B10TDP1USP2TSHRMEN1 | |
| Propylene Glycol SCHEMBL2748505 | 0.87 | HSD17B10 (0.58) | HSD17B10TDP1USP2TSHRHTT | |
| Propylene Glycol SCHEMBL23159801 | 0.86 | USP2 (0.62) | HSD17B10TDP1USP2TSHRMEN1 | |
| Propylene Glycol SCHEMBL122754 | 0.86 | HSD17B10 (0.52) | HSD17B10TDP1USP2TSHRMEN1 | |
| Propylene Glycol SCHEMBL445698 | 0.84 | HSD17B10 (0.50) | HSD17B10TDP1USP2TSHRMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105940065-A | Method for manufacturing aqueous black pigment dispersion | DIC株式会社 | 2016-09-14 | — | — | CN | disclosed |