Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Propylene Glycol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 5/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | USP2 | O75604 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CASP1 | P29466 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.32 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Propylene Glycol SCHEMBL15353567 | 0.93 | HSD17B10 (0.58) | HSD17B10TSHRTDP1MAPK1MEN1 | |
| Propylene Glycol SCHEMBL10765776 | 0.93 | HSD17B10 (0.64) | HSD17B10TSHRTDP1MAPK1MEN1 | |
| Propylene Glycol SCHEMBL56047 | 0.93 | HSD17B10 (0.64) | HSD17B10TSHRTDP1MAPK1MEN1 | |
| Propylene Glycol SCHEMBL10613711 | 0.90 | HSD17B10 (0.61) | HSD17B10TSHRTDP1MAPK1MEN1 | |
| Propylene Glycol SCHEMBL28092305 | 0.90 | HSD17B10 (0.61) | HSD17B10TSHRTDP1MAPK1MEN1 | |
| Di(Hydroxyethyl)Ether SCHEMBL1712817 | 0.90 | TSHR (0.59) | HSD17B10TSHRTDP1MAPK1MEN1 | |
| Di(Hydroxyethyl)Ether SCHEMBL3063890 | 0.90 | TSHR (0.59) | HSD17B10TSHRTDP1MAPK1MEN1 | |
| Triethylene Glycol SCHEMBL6869496 | 0.87 | MEN1 (0.61) | HSD17B10TSHRTDP1MAPK1MEN1 | |
| Tetraethylene Glycol SCHEMBL8850597 | 0.87 | MEN1 (0.61) | HSD17B10TSHRTDP1MAPK1MEN1 | |
| Propylene Glycol SCHEMBL3359839 | 0.87 | MEN1 (0.61) | HSD17B10TSHRTDP1MAPK1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140112987-A1 | GASTRORESISTANT PHARMACEUTICAL FORMULATIONS CONTAINING RIFAXIMIN | ALFA WASSERMANN S.P.A. (IT) | 2014-04-24 | — | — | US | claimed |
| WO-2013160092-A1 | HARD SURFACE TREATMENT COMPOSITION | UNILEVER N.V. (NL) | 2013-10-31 | — | — | WO | disclosed |
| US-20100133465-A1 | DISPERSANT CONTAINING METAL COMPLEX FOR CARBON NANOTUBE | LG CHEM, LTD. (KR) | 2010-06-03 | — | — | US | disclosed |
| EP-2148835-A2 | DISPERSANT CONTAINING METAL COMPLEX FOR CARBON NANOTUBE | LG Chem, Ltd. (KR) | 2010-02-03 | — | — | EP | disclosed |
| WO-2008147137-A2 | DISPERSANT CONTAINING METAL COMPLEX FOR CARBON NANOTUBE | LG CHEM, LTD. (KR) | 2008-12-04 | — | — | WO | disclosed |
| US-7396397-B2 | Ink composition for oil-based ballpoint pen and method for production thereof, and ballpoint pen refill | KABUSHIKI KAISHA PILOT CORPORATION (JP) | 2008-07-08 | — | — | US | disclosed |
| US-20060156950-A1 | Oil-based ballpoint ink composition, process for production thereof, and ballpoint refill | KABUSHIKI KAISHA PILOT CORPORATION (JP) | 2006-07-20 | — | — | US | disclosed |
| EP-1595924-A1 | OIL-BASED BALLPOINT INK COMPOSITION, PROCESS FOR PRODUCTION THEREOF, AND BALLPOINT REFILL | Kabushiki Kaisha Pilot Corporation (JP) | 2005-11-16 | — | — | EP | disclosed |