Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 2/20 | 0.50 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | NR0B1 | P51843 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | RARB | P10826 | 6/20 | 0.40 |
| ▸ | RARG | P13631 | 6/20 | 0.40 |
| ▸ | RARA | P10276 | 4/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28093367 | 0.78 | NOTUM (0.55) | NOTUMESR2MEN1KMT2ARARB | |
| SCHEMBL7793710 | 0.75 | RARB (0.62) | ESR2RARBRARGRARARXRA | |
| SCHEMBL8982307 | 0.74 | NOTUM (0.49) | NOTUMMAPTRARBRARGRARA | |
| SCHEMBL18165267 | 0.73 | NOTUM (0.42) | NOTUMPGRBACE1APP | |
| SCHEMBL28085951 | 0.72 | ALDH1A1 (0.34) | MEN1KMT2ASMN1; SMN2BCL2L1ALDH1A1 | |
| SCHEMBL27951061 | 0.72 | PGR (0.46) | ESR2MEN1NPC1NFKB1RAB9A | |
| SCHEMBL21776892 | 0.71 | NOTUM (0.61) | NOTUMNPC1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL27466656 | 0.71 | BCL2L1 (0.59) | ESR2MEN1NPC1USP2LMNA | |
| SCHEMBL28076731 | 0.71 | MAPT (0.63) | ESR2MEN1NPC1USP2LMNA | |
| SCHEMBL626173 | 0.70 | ESR2 (0.46) | ESR2BCL2L1ALDH1A1HPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103596943-B | Hydantoin derivatives useful as KV3 inhibitors | 奥蒂福尼疗法有限公司 | 2016-10-12 | — | — | CN | disclosed |