Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 4/20 | 0.40 |
| ▸ | EHMT2 | Q96KQ7 | 2/20 | 0.39 |
| ▸ | DNMT3A | Q9Y6K1 | 2/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | EED | O75530 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | MLNR | O43193 | 1/20 | 0.37 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HLA-A | P04439 | 1/20 | 0.37 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | LCK | P06239 | 1/20 | 0.37 |
| ▸ | FYN | P06241 | 1/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2810273 | 0.92 | ADORA3 (0.41) | MAPTMEN1CYP1A2CYP3A4ADORA3 | |
| SCHEMBL2813941 | 0.92 | ADORA3 (0.41) | MAPTMEN1CYP1A2CYP3A4ADORA3 | |
| SCHEMBL2813871 | 0.89 | MRGPRX1 (0.39) | MAPTFYNHTR7SSTR5GRK6 | |
| SCHEMBL2809538 | 0.85 | EHMT2 (0.41) | CNR2EHMT2DNMT3AKCNH2MAPT | |
| SCHEMBL2813066 | 0.85 | ACHE (0.38) | EHMT2DNMT3AMAPTMEN1TP53 | |
| SCHEMBL2813035 | 0.84 | MCHR1 (0.36) | EHMT2MAPTSIGMAR1 | |
| SCHEMBL537584 | 0.84 | ACHE (0.45) | EHMT2DNMT3AMAPTMEN1HRH1 | |
| SCHEMBL2812933 | 0.84 | CLK4 (0.41) | MAPTMEN1LMNATP53KMT2A | |
| SCHEMBL2811115 | 0.84 | MAPT (0.40) | EHMT2MAPTMLNRCHRM2ADORA3 | |
| SCHEMBL2812056 | 0.84 | CXCR3 (0.37) | MAPTMEN1DRD2DRD4HTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8343983-B2 | Substituted pyrazolo-pyrimidine compounds | ARQULE, INC. (US) | 2013-01-01 | — | — | US | disclosed |
| US-20100249110-A1 | SUBSTITUTED PYRAZOLO-PYRIMIDINE COMPOUNDS | ARQULE, INC. (US) | 2010-09-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100249110-A1 | SUBSTITUTED PYRAZOLO-PYRIMIDINE COMPOUNDS | DPYD, TYMP, TP53 | CNR2 1666/4885EHMT2 3441/4885DNMT3A 2966/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.