Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7674650 | 0.82 | TSHR (0.39) | POLBHTTSMN1; SMN2TSHRLMNA | |
| SCHEMBL12466487 | 0.81 | SMN1; SMN2 (0.38) | POLBHTTSMN1; SMN2TSHRLMNA | |
| SCHEMBL5116443 | 0.81 | GAA (0.40) | POLBHTTSMN1; SMN2TSHRGAA | |
| SCHEMBL287221 | 0.79 | SMN1; SMN2 (0.37) | POLBHTTSMN1; SMN2TSHRLMNA | |
| SCHEMBL5252228 | 0.79 | CYP19A1 (0.55) | HTTSMN1; SMN2TSHRLMNAALDH1A1 | |
| SCHEMBL3717744 | 0.78 | SMN1; SMN2 (0.36) | POLBHTTSMN1; SMN2TSHRLMNA | |
| SCHEMBL9570744 | 0.77 | HTT (0.57) | POLBHTTSMN1; SMN2NPBWR1TSHR | |
| SCHEMBL5495288 | 0.77 | HTT (0.57) | POLBHTTSMN1; SMN2TSHRLMNA | |
| SCHEMBL24534037 | 0.77 | ALDH1A1 (0.39) | POLBHTTSMN1; SMN2TSHRLMNA | |
| SCHEMBL14782135 | 0.75 | POLB (0.49) | POLBSMN1; SMN2TSHRLMNACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105916503-A | Heteroaryls and uses thereof | 米伦纽姆医药公司 | 2016-08-31 | — | — | CN | disclosed |