Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL287221 | 0.87 | SMN1; SMN2 (0.37) | SMN1; SMN2POLBTSHRALDH1A1LMNA | |
| SCHEMBL7674650 | 0.79 | TSHR (0.39) | SMN1; SMN2POLBTSHRALDH1A1LMNA | |
| SCHEMBL5116443 | 0.78 | GAA (0.40) | SMN1; SMN2POLBTSHRRXFP1ALDH1A1 | |
| SCHEMBL12466487 | 0.78 | SMN1; SMN2 (0.38) | SMN1; SMN2POLBTSHRALDH1A1LMNA | |
| SCHEMBL28094372 | 0.78 | POLB (0.44) | SMN1; SMN2POLBTSHRRXFP1ALDH1A1 | |
| SCHEMBL5252228 | 0.76 | CYP19A1 (0.55) | SMN1; SMN2TSHRALDH1A1LMNAHTT | |
| SCHEMBL24534037 | 0.74 | ALDH1A1 (0.39) | SMN1; SMN2POLBTSHRALDH1A1LMNA | |
| SCHEMBL3718150 | 0.73 | TSHR (0.62) | POLBTSHRALDH1A1LMNAMAPT | |
| SCHEMBL14782135 | 0.72 | POLB (0.49) | SMN1; SMN2POLBTSHRALDH1A1LMNA | |
| Ethylene SCHEMBL28777120 | 0.72 | CYP19A1 (0.50) | SMN1; SMN2TSHRALDH1A1LMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010128058-A1 | DIHYDROPYRIMIDINONES FOR USE AS BACE2 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2010-11-11 | — | — | WO | disclosed |