Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 4/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28094372 | 0.82 | POLB (0.44) | TSHRPOLBSMN1; SMN2ATMALDH1A1 | |
| SCHEMBL5116443 | 0.82 | GAA (0.40) | TSHRPOLBSMN1; SMN2ATMALDH1A1 | |
| SCHEMBL12466487 | 0.82 | SMN1; SMN2 (0.38) | TSHRPOLBSMN1; SMN2ALDH1A1CYP19A1 | |
| SCHEMBL287221 | 0.81 | SMN1; SMN2 (0.37) | TSHRPOLBSMN1; SMN2ATMALDH1A1 | |
| SCHEMBL5252228 | 0.80 | CYP19A1 (0.55) | TSHRSMN1; SMN2ALDH1A1CYP19A1LMNA | |
| SCHEMBL3717744 | 0.79 | SMN1; SMN2 (0.36) | TSHRPOLBSMN1; SMN2ATMALDH1A1 | |
| SCHEMBL24534037 | 0.78 | ALDH1A1 (0.39) | TSHRPOLBSMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL14782135 | 0.77 | POLB (0.49) | TSHRPOLBSMN1; SMN2ALDH1A1CYP19A1 | |
| SCHEMBL11494117 | 0.76 | CYP19A1 (0.56) | TSHRPOLBSMN1; SMN2ALDH1A1CYP19A1 | |
| Ethylene SCHEMBL28777120 | 0.76 | CYP19A1 (0.50) | TSHRSMN1; SMN2ALDH1A1CYP19A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6476021-B1 | Compounds having cGMP-PDE inhibitory effect | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2002-11-05 | — | — | US | disclosed |
| EP-1048666-A1 | NOVEL COMPOUNDS HAVING cGMP-PDE INHIBITORY EFFECT | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2000-11-02 | — | — | EP | disclosed |