SCHEMBL28095287

SCHEMBL28095287

O=C(C(CNc1ccccc1)c1ccc(Br)cc1)C(CNc1ccccc1)c1ccc(Br)cc1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CNR1 P21554 4/20 0.49
MAOA P21397 1/20 0.46
MAOB P27338 1/20 0.46
CNR2 P34972 2/20 0.44
MEN1 O00255 3/20 0.44
KMT2A Q03164 3/20 0.44
S1PR3 Q99500 1/20 0.44
ALDH1A1 P00352 3/20 0.43
MAPT P10636 2/20 0.43
SMN1; SMN2 Q16637 1/20 0.42
DNM1 Q05193 1/20 0.42
SLC6A2 P23975 1/20 0.41
SLC6A4 P31645 1/20 0.41
SLC6A3 Q01959 1/20 0.41
FPR2 P25090 1/20 0.40
TP53 P04637 1/20 0.40
HTR2A P28223 1/20 0.40
KDM4E B2RXH2 1/20 0.39
CRHBP P24387 1/20 0.39
CRHR2 Q13324 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27568201 0.94 MEN1 (0.51) CNR1MAOAMAOBCNR2MEN1
SCHEMBL28044003 0.88 ALDH1A1 (0.45) MEN1KMT2AALDH1A1MAPTSMN1; SMN2
SCHEMBL13285509 0.78 CYP2C19 (0.50) ALDH1A1MAPTSMN1; SMN2
SCHEMBL27711293 0.77 APAF1 (0.56) MEN1KMT2AALDH1A1SMN1; SMN2SLC6A2
SCHEMBL27711189 0.77 APAF1 (0.56) MEN1KMT2AALDH1A1SMN1; SMN2SLC6A2
SCHEMBL27711250 0.76 CNR2 (0.51) CNR1CNR2KMT2A
SCHEMBL27604324 0.75 CYP24A1 (0.55) MEN1KMT2AALDH1A1MAPTSMN1; SMN2
SCHEMBL28095288 0.74 MAPT (0.43) CNR1MAOAMAOBCNR2MEN1
SCHEMBL9285815 0.74 SMN1; SMN2 (0.56) CNR1CNR2MEN1KMT2AALDH1A1
SCHEMBL9290103 0.73 ALDH1A1 (0.49) CNR1CNR2MEN1KMT2AALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-106243053-B A kind of triazolylamide ketone fungicide, synthetic method and its application 三峡大学 2018-09-28 CN disclosed
CN-106243053-A A kind of triazolylamide ketone antibacterial, synthetic method and application thereof 三峡大学 2016-12-21 CN disclosed