Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | HBB | P68871 | 2/20 | 0.53 |
| ▸ | GMNN | O75496 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | PGR | P06401 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.53 |
| ▸ | BLM | P54132 | 1/20 | 0.53 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | ATM | Q13315 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | GFER | P55789 | 3/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Thiamiprine SCHEMBL27866409 | 0.85 | MAPT (0.47) | MAPTLMNAHBBGMNNTP53 | |
| Thiamiprine SCHEMBL28239157 | 0.80 | MAPT (0.41) | MAPTLMNAHBBGMNNTP53 | |
| Thiamiprine SCHEMBL4852 | 0.76 | CYP1A2 (0.56) | MAPTLMNAHBBGMNNTP53 | |
| Thiamiprine SCHEMBL29350246 | 0.76 | CYP1A2 (0.56) | MAPTLMNAHBBGMNNTP53 | |
| Azathioprine SCHEMBL3261116 | 0.74 | MAPT (0.68) | MAPTLMNAHBBGMNNTP53 | |
| Azathioprine SCHEMBL29693611 | 0.70 | MAPT (1.00) | MAPTLMNAHBBGMNNTP53 | |
| Azathioprine SCHEMBL4278 | 0.70 | MAPT (1.00) | MAPTLMNAHBBGMNNTP53 | |
| Azathioprine SCHEMBL4436347 | 0.70 | MAPT (1.00) | MAPTLMNAHBBGMNNTP53 | |
| Thiamiprine SCHEMBL4851 | 0.70 | MAPT (0.71) | MAPTLMNAHBBGMNNTP53 | |
| Azathioprine SCHEMBL3089846 | 0.69 | MAPT (0.98) | MAPTLMNAHBBGMNNTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105848680-A | Treatment using bruton's tyrosine kinase inhibitors and immunotherapy | 药品循环有限责任公司 | 2016-08-10 | — | — | CN | disclosed |