Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Thiamiprine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.41 |
| ▸ | HBB | P68871 | 3/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | GMNN | O75496 | 1/20 | 0.41 |
| ▸ | PGR | P06401 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.37 |
| ▸ | XDH | P47989 | 1/20 | 0.37 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Thiamiprine SCHEMBL27866409 | 0.93 | MAPT (0.47) | MAPTHBBTP53SMN1; SMN2LMNA | |
| Thiamiprine SCHEMBL28142582 | 0.85 | HBB (0.36) | MAPTHBBTP53SMN1; SMN2LMNA | |
| Thiamiprine SCHEMBL28095327 | 0.80 | MAPT (0.53) | MAPTHBBTP53SMN1; SMN2LMNA | |
| Thioguanine SCHEMBL27787425 | 0.71 | ALDH1A1 (0.72) | HBBTP53SMN1; SMN2LMNACYP3A4 | |
| Azathioprine SCHEMBL5716607 | 0.67 | MAPT (0.67) | MAPTHBBTP53SMN1; SMN2LMNA | |
| Thiamiprine SCHEMBL29350246 | 0.67 | CYP1A2 (0.56) | MAPTHBBTP53SMN1; SMN2LMNA | |
| Thiamiprine SCHEMBL4852 | 0.67 | CYP1A2 (0.56) | MAPTHBBTP53SMN1; SMN2LMNA | |
| Thiamiprine SCHEMBL15284276 | 0.66 | MAPT (0.59) | MAPTHBBTP53SMN1; SMN2LMNA | |
| Azathioprine SCHEMBL8018151 | 0.65 | MAPT (0.75) | MAPTHBBTP53SMN1; SMN2LMNA | |
| Azathioprine SCHEMBL8354969 | 0.65 | MAPT (0.82) | MAPTHBBTP53SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110325533-A | INHIBITORS OF THE MENIN-MLL INTERACTION | 生命医药有限责任公司 | 2019-10-11 | — | — | CN | disclosed |
| CN-109414436-A | Treatment of hematological malignancies with 2- (4-chlorophenyl) -N- ((2- (2, 6-dioxopiperidin-3-yl) -1-oxoisoindolin-5-yl) methyl) -2, 2-difluoroacetamide | 细胞基因公司 | 2019-03-01 | — | — | CN | disclosed |
| CN-108712904-A | The solid form of two Fluorakil 100s of 2- (4- chlorphenyls)-N- ((2- (2,6- dioxopiperidine -3- bases) -1- oxoisoindolines -5- bases) methyl) -2,2- and its pharmaceutical composition and purposes | 细胞基因公司 | 2018-10-26 | — | — | CN | disclosed |
| CN-108430473-A | Antiproliferative compounds and pharmaceutical compositions and uses thereof | 细胞基因公司 | 2018-08-21 | — | — | CN | disclosed |