SCHEMBL28095368

SCHEMBL28095368

CCC(Br)c1cc(F)c(C(=O)c2ccccc2)c(F)c1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HKDC1 Q2TB90 1/20 0.41
AKR1C3 P42330 2/20 0.40
AKR1C2 P52895 2/20 0.40
ALDH1A1 P00352 3/20 0.40
RAB9A P51151 1/20 0.40
SMN1; SMN2 Q16637 3/20 0.39
MAPT P10636 2/20 0.39
PTGS1 P23219 2/20 0.39
CXCR1 P25024 2/20 0.39
CXCR2 P25025 2/20 0.39
PTGS2 P35354 2/20 0.39
RECQL P46063 1/20 0.39
KDM4E B2RXH2 1/20 0.39
LMNA P02545 1/20 0.39
CYP3A4 P08684 1/20 0.39
HPGD P15428 1/20 0.39
MAPK1 P28482 1/20 0.39
PMP22 Q01453 1/20 0.39
SLC22A6 Q4U2R8 1/20 0.39
HSD17B10 Q99714 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28095147 0.79 ALDH1A1 (0.53) ALDH1A1RAB9ASMN1; SMN2MAPTPTGS1
SCHEMBL4187835 0.73 ALDH1A1 (0.54) AKR1C3ALDH1A1RAB9ASMN1; SMN2LMNA
SCHEMBL14920489 0.71
SCHEMBL8068391 0.70 SHBG (0.39)
SCHEMBL27896595 0.70 MAPT (0.49) AKR1C3ALDH1A1RAB9ASMN1; SMN2MAPT
SCHEMBL1420986 0.68 ALDH1A1 (0.59) AKR1C3ALDH1A1RAB9AHPGDATM
SCHEMBL83018 0.68 LMNA (0.52) HKDC1LMNATDP1
SCHEMBL30034760 0.68 LMNA (0.52) HKDC1LMNATDP1
Hydrochloric Acid SCHEMBL28970405 0.66 LMNA (0.50) HKDC1LMNACYP3A4TDP1
SCHEMBL5006192 0.66 LMNA (0.50) HKDC1LMNATDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-104860808-B Two fluorine monomers containing tetraphenyl ethylene group and be used for preparing poly aryl ether ketone polymer 吉林大学 2016-09-07 CN disclosed