Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.63 |
| ▸ | MEN1 | O00255 | 1/20 | 0.63 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.55 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.55 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.55 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.55 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.55 |
| ▸ | PHGDH | O43175 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 4/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 4/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3659889 | 0.85 | KMT2A (0.65) | KMT2AMEN1KCNMA1PDK1PDK2 | |
| SCHEMBL11332310 | 0.80 | KMT2A (0.73) | KMT2AMEN1KCNMA1PDK1PDK2 | |
| SCHEMBL6857920 | 0.80 | KMT2A (0.73) | KMT2AMEN1KCNMA1PDK1PDK2 | |
| SCHEMBL6535747 | 0.80 | KMT2A (0.62) | KMT2AMEN1KCNMA1PDK1PDK2 | |
| SCHEMBL1733957 | 0.80 | PDK1 (0.58) | KMT2AMEN1KCNMA1PDK1PDK2 | |
| SCHEMBL1745798 | 0.79 | KMT2A (0.71) | KMT2AMEN1KCNMA1PDK1PDK2 | |
| SCHEMBL30388225 | 0.79 | KMT2A (0.71) | KMT2AMEN1KCNMA1PDK1PDK2 | |
| SCHEMBL175272 | 0.79 | MEN1 (0.71) | KMT2AMEN1KCNMA1PDK1PDK2 | |
| SCHEMBL6377318 | 0.79 | KMT2A (0.71) | KMT2AMEN1KCNMA1PDK1PDK2 | |
| SCHEMBL113558 | 0.79 | MEN1 (0.71) | KMT2AMEN1KCNMA1PDK1PDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110354128-A | Pyrimidine FGFR4 inhibitors | 卫材R&D管理有限公司 | 2019-10-22 | — | — | CN | disclosed |
| CN-105899490-B | Pyrimidine FGFR4 Inhibitors | 卫材R&D管理有限公司 | 2019-07-23 | — | — | CN | disclosed |
| CN-105899490-A | Pyrimidine fgfr4 inhibitors | 卫材R&D管理有限公司 | 2016-08-24 | — | — | CN | disclosed |