Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 1/20 | 0.33 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.33 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.33 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.33 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | CA12 | O43570 | 1/20 | 0.30 |
| ▸ | CA1 | P00915 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | CA9 | Q16790 | 1/20 | 0.30 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27731317 | 0.80 | TSHR (0.32) | MAPTHSD17B10CA12CA1CA2 | |
| Hydrochloric Acid SCHEMBL27621252 | 0.79 | TSHR (0.31) | CA12CA1CA2CA9CA14 | |
| SCHEMBL4695233 | 0.71 | — | — | |
| SCHEMBL25195357 | 0.70 | CA12 (0.34) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| Benzene SCHEMBL27551913 | 0.70 | — | — | |
| Hydrochloric Acid SCHEMBL27029865 | 0.69 | CA12 (0.33) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| Formaldehyde SCHEMBL27781384 | 0.68 | — | — | |
| SCHEMBL4334920 | 0.67 | ALDH1A1 (0.30) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL7982624 | 0.67 | TP53 (0.34) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL29600745 | 0.66 | TP53 (0.31) | GABRA1GABRG2GABRB3GABRA3GABRA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118119626-A | Fused bicyclic heteroaryl compounds useful as NLRP3 inhibitors | 豪夫迈·罗氏有限公司 | 2024-05-31 | — | — | CN | disclosed |
| CN-118005640-A | GCN2 inhibitors and uses thereof | 默克专利股份有限公司 | 2024-05-10 | — | — | CN | disclosed |
| CN-108707140-B | Protease C inhibitors | 勃林格殷格翰国际有限公司 | 2022-07-22 | — | — | CN | disclosed |
| CN-114401969-A | Heterocyclic compounds | 豪夫迈·罗氏有限公司 | 2022-04-26 | — | — | CN | disclosed |
| CN-110475777-B | Novel pyrido [2,3-b ] indole compounds for the treatment and prevention of bacterial infections | 豪夫迈·罗氏有限公司 | 2022-04-15 | — | — | CN | disclosed |
| CN-114364684-A | Heterocyclic compounds | 豪夫迈·罗氏有限公司 | 2022-04-15 | — | — | CN | disclosed |
| CN-109790169-B | Cyanopyrrolidine derivatives having activity as USP30 inhibitors | 特殊治疗有限公司 | 2022-03-29 | — | — | CN | disclosed |
| CN-111936494-A | Substituted hydro-pyrido-azines as sodium channel inhibitors | 豪夫迈·罗氏有限公司 | 2020-11-13 | — | — | CN | disclosed |
| CN-105916848-B | Kinase inhibitors and uses thereof | 山东轩竹医药科技有限公司 | 2018-01-09 | — | — | CN | disclosed |
| CN-105916848-A | Kinase inhibitors and uses thereof | 山东轩竹医药科技有限公司 | 2016-08-31 | — | — | CN | disclosed |