Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.64 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.64 |
| ▸ | HTR1A | P08908 | 2/20 | 0.64 |
| ▸ | POLB | P06746 | 2/20 | 0.64 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.64 |
| ▸ | HTR6 | P50406 | 1/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.64 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.64 |
| ▸ | MAPT | P10636 | 14/20 | 0.62 |
| ▸ | TP53 | P04637 | 1/20 | 0.62 |
| ▸ | HTT | P42858 | 2/20 | 0.61 |
| ▸ | NPC1 | O15118 | 1/20 | 0.61 |
| ▸ | RAB9A | P51151 | 1/20 | 0.61 |
| ▸ | TDO2 | P48775 | 1/20 | 0.60 |
| ▸ | DRD2 | P14416 | 1/20 | 0.60 |
| ▸ | HTR2A | P28223 | 1/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11864713 | 0.88 | LMNA (0.66) | LMNAKDM4EALOX15HTR1APOLB | |
| SCHEMBL18324889 | 0.85 | LMNA (0.58) | LMNAKDM4EALOX15HTR1APOLB | |
| SCHEMBL18324901 | 0.85 | LMNA (0.66) | LMNAKDM4EALOX15HTR1APOLB | |
| SCHEMBL3226626 | 0.83 | MAPT (0.66) | LMNAKDM4EALOX15HTR1APOLB | |
| SCHEMBL20740133 | 0.83 | MAPT (0.47) | LMNAKDM4EALOX15HTR1APOLB | |
| SCHEMBL31385885 | 0.83 | MAPT (0.57) | LMNAKDM4EALOX15HTR1APOLB | |
| SCHEMBL28097370 | 0.83 | TDO2 (0.65) | LMNAKDM4EALOX15HTR1ASLC6A4 | |
| SCHEMBL14875491 | 0.83 | HTR2A (0.48) | LMNAKDM4EALOX15HTR1APOLB | |
| SCHEMBL28097371 | 0.83 | MAPT (0.54) | LMNAPOLBSLC6A4MAPTTP53 | |
| SCHEMBL1703585 | 0.83 | SLC6A4 (0.67) | LMNAHTR1ASLC6A4HTR6MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111848598-A | Heterocyclic ring-containing compound, application thereof and composition containing heterocyclic ring-containing compound | 健艾仕生物医药有限公司 | 2020-10-30 | — | — | CN | disclosed |
| CN-106045966-B | Substituted heterocyclic compounds and their use in medicine | 广东东阳光药业有限公司 | 2020-04-21 | — | — | CN | disclosed |
| CN-106045967-B | Substituted heterocyclic compounds and their use in medicine | 广东东阳光药业有限公司 | 2020-04-21 | — | — | CN | disclosed |
| CN-106045966-A | Substituted heterocyclic compounds and application of same to medicines | 广东东阳光药业有限公司 | 2016-10-26 | — | — | CN | disclosed |
| CN-106045967-A | Substituted heterocyclic compounds and application of same to medicines | 广东东阳光药业有限公司 | 2016-10-26 | — | — | CN | disclosed |