Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | PDE7A | Q13946 | 3/20 | 0.45 |
| ▸ | MGLL | Q99685 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 5/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
| ▸ | THPO | P40225 | 1/20 | 0.44 |
| ▸ | MTOR | P42345 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28099900 | 0.89 | KMT2A (0.51) | KMT2AHSD17B10MEN1MAPTMAPK1 | |
| SCHEMBL27587702 | 0.85 | MGLL (0.45) | KMT2AMGLLMEN1MAPTMAPK1 | |
| SCHEMBL7945716 | 0.84 | ALDH1A1 (0.53) | KMT2AHSD17B10PDE7AMGLLMEN1 | |
| SCHEMBL28834470 | 0.83 | KMT2A (0.48) | KMT2AHSD17B10PDE7AMEN1MAPT | |
| SCHEMBL27556186 | 0.82 | SMN1; SMN2 (0.47) | KMT2AMGLLMEN1MAPTMAPK1 | |
| SCHEMBL1305384 | 0.81 | PSEN1 (0.46) | KMT2APDE7AMEN1MAPTMAPK1 | |
| SCHEMBL11291473 | 0.79 | ALDH1A1 (0.62) | KMT2AMGLLMEN1MAPTMAPK1 | |
| SCHEMBL6820216 | 0.79 | KMT2A (0.46) | KMT2AHSD17B10MEN1MAPTMAPK1 | |
| SCHEMBL16879411 | 0.79 | TSHR (0.53) | KMT2AMGLLMEN1LMNATP53 | |
| SCHEMBL28100008 | 0.79 | CYP3A4 (0.50) | KMT2AHSD17B10MEN1MAPTCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105884699-B | 4- substituted aniline quinazoline derivative and its preparation method and application | 中国药科大学 | 2019-05-07 | — | — | CN | disclosed |
| CN-105884699-A | 4-substituted anilinoquinazoline derivatives, and preparation method and application thereof | 中国药科大学 | 2016-08-24 | — | — | CN | disclosed |