Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 3/20 | 0.44 |
| ▸ | FLT1 | P17948 | 2/20 | 0.44 |
| ▸ | FLT4 | P35916 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 6/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | HTT | P42858 | 5/20 | 0.41 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | GMNN | O75496 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28099896 | 0.89 | KMT2A (0.51) | KMT2AHSD17B10MAPTSMN1; SMN2NPC1 | |
| SCHEMBL1305384 | 0.81 | PSEN1 (0.46) | KMT2AMAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL27605699 | 0.79 | GPR35 (0.46) | KMT2AMAPTSMN1; SMN2ALDH1A1HTT | |
| SCHEMBL28099849 | 0.79 | CYP3A4 (0.41) | KMT2AHSD17B10MAPTSMN1; SMN2NPC1 | |
| SCHEMBL1305387 | 0.78 | MAPT (0.42) | KMT2AMAPTSMN1; SMN2ALDH1A1HTT | |
| SCHEMBL28834470 | 0.78 | KMT2A (0.48) | KMT2AHSD17B10MAPTSMN1; SMN2NPC1 | |
| SCHEMBL27587720 | 0.76 | GPR35 (0.43) | KMT2AMAPTSMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL1177204 | 0.76 | TSHR (0.57) | KMT2AMAPTALDH1A1MEN1TDP1 | |
| SCHEMBL27587702 | 0.74 | MGLL (0.45) | KMT2AMAPTSMN1; SMN2ALDH1A1HTT | |
| SCHEMBL6820216 | 0.74 | KMT2A (0.46) | KMT2AHSD17B10MAPTSMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105884699-B | 4- substituted aniline quinazoline derivative and its preparation method and application | 中国药科大学 | 2019-05-07 | — | — | CN | disclosed |
| CN-105884699-A | 4-substituted anilinoquinazoline derivatives, and preparation method and application thereof | 中国药科大学 | 2016-08-24 | — | — | CN | disclosed |