Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.50 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.50 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.49 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 2/20 | 0.41 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | USP2 | O75604 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.40 |
| ▸ | KMO | O15229 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1850468 | 0.89 | MAP4K1 (0.52) | HSP90AA1HSP90AB1ASIC3ALDH1A1USP2 | |
| SCHEMBL30507282 | 0.81 | CYP1A2 (0.58) | HSP90AA1HSP90AB1ASIC3CHRNA7ALDH1A1 | |
| SCHEMBL1849244 | 0.81 | CYP1A2 (0.58) | HSP90AA1HSP90AB1ASIC3CHRNA7ALDH1A1 | |
| Hydrochloric Acid SCHEMBL2809031 | 0.80 | CYP1A2 (0.57) | HSP90AA1HSP90AB1ASIC3CHRNA7ALDH1A1 | |
| SCHEMBL3952084 | 0.76 | HSP90AA1 (0.71) | HSP90AA1HSP90AB1MCHR1CHRNA7ALDH1A1 | |
| SCHEMBL1849403 | 0.74 | USP2 (0.51) | ASIC3CHRNA7ALDH1A1USP2CYP1A2 | |
| SCHEMBL2812677 | 0.74 | ALDH1A1 (0.51) | EGFRCHRNA7ALDH1A1USP2CYP1A2 | |
| SCHEMBL558582 | 0.73 | ASIC3 (0.59) | ASIC3EGFRALDH1A1USP2CYP1A2 | |
| SCHEMBL2808407 | 0.73 | CDK9 (0.58) | ALDH1A1USP2CYP1A2CYP2C19CLK4 | |
| SCHEMBL28262348 | 0.73 | CYP1A2 (0.50) | HSP90AA1HSP90AB1CHRNA7ALDH1A1USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150038516-A1 | Inhibitors of Protein Kinases | ASTRAZENECA AB (SE) | 2015-02-05 | — | — | US | disclosed |
| US-8716296-B2 | Inhibitors of protein kinases | INGENIUM PHARMACEUTICALS GMBH (DE) | 2014-05-06 | — | — | US | disclosed |
| US-20100249149-A1 | Inhibitors of Protein Kinases | ASTRAZENECA AB (SE) | 2010-09-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100249149-A1 | Inhibitors of Protein Kinases | CDK9, CDK19, CDK2 | HSP90AA1 1225/4885HSP90AB1 1092/4885ASIC3 4447/4885 |
| US-20150038516-A1 | Inhibitors of Protein Kinases | CDK1, CDK2, CCNK | HSP90AA1 779/4885HSP90AB1 1048/4885ASIC3 4194/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.