Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.30 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16927716 | 0.78 | CHEK1 (0.33) | MAPTSMN1; SMN2HRH3 | |
| SCHEMBL2810093 | 0.74 | LMNA (0.34) | LMNAMAPTMAPK1HTTSMN1; SMN2 | |
| SCHEMBL2806094 | 0.74 | KEAP1 (0.37) | LMNAMAPTMAPK1HTTSMN1; SMN2 | |
| SCHEMBL2810097 | 0.73 | MAPT (0.37) | LMNAMAPTMAPK1HTTSMN1; SMN2 | |
| SCHEMBL2810697 | 0.73 | CLK2 (0.43) | — | |
| SCHEMBL13883760 | 0.73 | LMNA (0.34) | LMNAMAPTMAPK1HTTSMN1; SMN2 | |
| SCHEMBL2809795 | 0.73 | MAPT (0.35) | LMNAMAPTMAPK1HTTSMN1; SMN2 | |
| SCHEMBL2865558 | 0.72 | MAPT (0.37) | LMNAMAPTMAPK1HTTSMN1; SMN2 | |
| SCHEMBL13129755 | 0.71 | MAPT (0.35) | LMNAMAPTMAPK1HTTSMN1; SMN2 | |
| SCHEMBL16927761 | 0.70 | ENPP2 (0.46) | ENPP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8557824-B2 | Thiazole derivatives | MERCK PATENT GMBH (DE) | 2013-10-15 | — | — | US | claimed |
| US-20100240676-A1 | THIAZOLE DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2010-09-23 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100240676-A1 | THIAZOLE DERIVATIVES | CCNE2, PKD1, PKD2 | LMNA 1974/4885MAPT 1450/4885MAPK1 4175/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.