Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 9/20 | 0.46 |
| ▸ | EDNRA | P25101 | 9/20 | 0.46 |
| ▸ | PIN1 | Q13526 | 2/20 | 0.45 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.45 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.45 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | MMP8 | P22894 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15991494 | 1.00 | EDNRB (0.46) | EDNRBEDNRAPIN1NR1I2KCNE1 | |
| SCHEMBL2354447 | 0.85 | KMT2A (0.47) | EDNRBEDNRANR1I2KCNE1KCNQ1 | |
| SCHEMBL571027 | 0.85 | KMT2A (0.47) | EDNRBEDNRANR1I2KCNE1KCNQ1 | |
| SCHEMBL8013901 | 0.84 | ALDH1A1 (0.49) | EDNRBEDNRANR1I2KCNE1KCNQ1 | |
| SCHEMBL2362091 | 0.82 | CYP3A4 (0.44) | EDNRBEDNRANR1I2KCNE1KCNQ1 | |
| SCHEMBL2362095 | 0.82 | CYP3A4 (0.44) | EDNRBEDNRANR1I2KCNE1KCNQ1 | |
| SCHEMBL6779283 | 0.81 | PIN1 (0.49) | PIN1POLBMEN1NPC1KMT2A | |
| SCHEMBL27540519 | 0.81 | PIN1 (0.49) | PIN1POLBMEN1NPC1KMT2A | |
| SCHEMBL1067633 | 0.81 | EDNRB (0.50) | EDNRBEDNRANR1I2KCNE1KCNQ1 | |
| SCHEMBL570417 | 0.81 | EDNRB (0.50) | EDNRBEDNRANR1I2KCNE1KCNQ1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106011194-A | Preparation method of ambrisentan | 西安大唐制药集团有限公司 | 2016-10-12 | — | — | CN | disclosed |