Daptomycin

Daptomycin

SCHEMBL28102

CCCCCCCCCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H]1C(=O)NCC(=O)N[C@@H](CCCN)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](C)C(=O)N[C@@H](CC(=O)O)C(=O)NCC(=O)N[C@H](CO)C(=O)N[C@@H]([C@H](C)CC(=O)O)C(=O)N[C@@H](CC(=O)c2ccccc2N)C(=O)O[C@@H]1C

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CTSL P07711 1/20 1.00
DRD1 P21728 1/20 1.00
PTGS1 P23219 1/20 1.00
PDE4A P27815 1/20 1.00
F2 P00734 1/20 0.40
EPHA2 P29317 2/20 0.39
KEAP1 Q14145 2/20 0.38
KCNMA1 Q12791 1/20 0.38
KCNMB4 Q86W47 1/20 0.38
ALB P02768 1/20 0.37
F11 P03951 1/20 0.37
KRAS P01116 1/20 0.37
SSTR2 P30874 1/20 0.37
TSLP Q969D9 1/20 0.36
SHH Q15465 1/20 0.36
ITGB3 P05106 1/20 0.36
ITGAV P06756 1/20 0.36
NECTIN4 Q96NY8 2/20 0.36
OXTR P30559 1/20 0.36
ESR1 P03372 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Daptomycin SCHEMBL17253124 1.00 CTSL (1.00) CTSLDRD1PTGS1PDE4AF2
Daptomycin SCHEMBL28103 1.00 CTSL (1.00) CTSLDRD1PTGS1PDE4AF2
Daptomycin SCHEMBL13491700 1.00 CTSL (1.00) CTSLDRD1PTGS1PDE4AF2
Daptomycin SCHEMBL8221760 1.00 CTSL (1.00) CTSLDRD1PTGS1PDE4AF2
Daptomycin SCHEMBL8227262 1.00 CTSL (1.00) CTSLDRD1PTGS1PDE4AF2
Daptomycin SCHEMBL23046993 1.00 CTSL (1.00) CTSLDRD1PTGS1PDE4AF2
Daptomycin SCHEMBL17351683 1.00 CTSL (1.00) CTSLDRD1PTGS1PDE4AF2
Daptomycin SCHEMBL2724847 1.00 CTSL (1.00) CTSLDRD1PTGS1PDE4AF2
Daptomycin SCHEMBL21402170 1.00 CTSL (1.00) CTSLDRD1PTGS1PDE4AF2
Daptomycin SCHEMBL16274142 1.00 CTSL (1.00) CTSLDRD1PTGS1PDE4AF2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 22833 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4749288-A1 COMPOSITIONS FOR DETECTING, CHARACTERIZING, AND REMOVING A BIOFILM COSA Group GmbH (DE) 2026-05-27 EP claimed
WO-2026106551-A1 ANTIMICROBIAL PEPTIDE NANONETS AND METHODS OF USE THEREOF NATIONAL UNIVERSITY OF SINGAPORE (SG) 2026-05-21 WO claimed
WO-2026104587-A1 CYCLIC BORONIC ACID ESTERS USEFUL AS ADJUVANTS IN THE TREATMENT OF BACTERIAL INFECTIONS ADJUTEC PHARMA AS (NO) 2026-05-21 WO claimed
US-20260137753-A1 DAPTOMYCIN COMPOSITIONS MAIA PHARMACEUTICALS INC (US) 2026-05-21 US claimed
EP-4744648-A1 LIPOPEPTIDE-CONTAINING FAT-DISSOLVING PRODUCT, AND PREPARATION METHOD THEREFOR AND USE THEREOF Bloomage Biotechnology Corporation Limited (CN) 2026-05-20 EP claimed
CN-115215923-B Macrocyclic broad-spectrum antibiotics 豪夫迈·罗氏有限公司 2026-05-19 CN claimed
CN-122060030-A Preparation method of daptomycin beta isomer 泰州医药城国科化物生物医药科技有限公司 2026-05-19 CN claimed
US-12629337-B2 Daptomycin formulation HIKMA PHARMACEUTICALS USA INC. (US) 2026-05-19 US claimed
EP-4739326-A2 PRODUCTION & SECRETION OF AUXIN-LIKE MOLECULES IN BACTERIA SNIPR Biome ApS (DK) 2026-05-13 EP claimed
US-20260124148-A1 POLYPEPTIDE FORMULATIONS FOR ORAL DELIVERY BHAMIS RES LABORATORY PVT LTD (IN) 2026-05-07 US claimed
WO-2001032130-A2 PHENYL AMINE CARBOXYLIC ACID COMPOUNDS AND COMPOSITIONS FOR DELIVERING ACTIVE AGENTS EMISPHERE TECHNOLOGIES, INC. (US) 2001-05-10 WO claimed
EP-1087989-A1 IMPROVED PROCESS FOR PREPARING SCHIFF BASE ADDUCTS OF AMINES WITH O-HYDROXY ALDEHYDES AND COMPOSITIONS OF MATTER BASED THEREON Pfizer Products Inc. (US) 2001-04-04 EP claimed
WO-2000015207-B1 COMBINATION FOR THE TREATMENT OF INFLAMMATION USING ELASTINE INHIBITOR(S) AND ANTIBACTERIAL AGENT(S) NAEJA PHARMACEUTICAL INC (CA) 2000-07-13 WO claimed
WO-2000018419-A2 METHODS FOR ADMINISTRATION OF ANTIBIOTICS CUBIST PHARMACEUTICALS, INC. (US) 2000-04-06 WO claimed
WO-2000015207-A2 COMBINATION FOR THE TREATMENT OF INFLAMMATION USING ELASTINE INHIBITOR(S) AND ANTIBACTERIAL AGENT(S) NAEJA PHARMACEUTICAL INC. (US) 2000-03-23 WO claimed
WO-2000000507-A1 IMPROVED PROCESS FOR PREPARING SCHIFF BASE ADDUCTS OF AMINES WITH O-HYDROXY ALDEHYDES AND COMPOSITIONS OF MATTER BASED THEREON PFIZER PRODUCTS INC. (US) 2000-01-06 WO claimed
CN-1054537-A IMPROVED DILUENT FORMULATION FOR DAPTOMYCIN LILLY CO ELI (US) 1991-09-18 CN claimed
EP-0386951-A2 An improved diluent formulation for daptomycin ELI LILLY AND COMPANY (US) 1990-09-12 EP claimed
US-4874843-A Chromatographic purification process ELI LILLY AND COMPANY (US) 1989-10-17 US claimed
EP-0294990-A2 Chromatographic purification process ELI LILLY AND COMPANY (US) 1988-12-14 EP claimed