Daptomycin

Daptomycin

SCHEMBL1650768

CCCCCCCCCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(=O)O)C(=O)NC1C(=O)NCC(=O)N[C@@H](CCCN)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](C)C(=O)N[C@@H](CC(=O)O)C(=O)NCC(=O)N[C@H](CO)C(=O)N[C@@H](C(C)CC(=O)O)C(=O)N[C@@H](CC(=O)c2ccccc2N)C(=O)OC1C

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CTSL P07711 1/20 1.00
▸ DRD1 P21728 1/20 1.00
▸ PTGS1 P23219 1/20 1.00
▸ PDE4A P27815 1/20 1.00
▸ F2 P00734 1/20 0.40
▸ EPHA2 P29317 2/20 0.39
▸ KEAP1 Q14145 2/20 0.38
▸ KCNMA1 Q12791 1/20 0.38
▸ KCNMB4 Q86W47 1/20 0.38
▸ ALB P02768 1/20 0.37
▸ F11 P03951 1/20 0.37
▸ KRAS P01116 1/20 0.37
▸ SSTR2 P30874 1/20 0.37
▸ TSLP Q969D9 1/20 0.36
▸ SHH Q15465 1/20 0.36
▸ ITGB3 P05106 1/20 0.36
▸ ITGAV P06756 1/20 0.36
▸ NECTIN4 Q96NY8 2/20 0.36
▸ OXTR P30559 1/20 0.36
▸ ESR1 P03372 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Daptomycin SCHEMBL28102 1.00 CTSL (1.00) CTSLDRD1PTGS1PDE4AF2
Daptomycin SCHEMBL17253124 1.00 CTSL (1.00) CTSLDRD1PTGS1PDE4AF2
Daptomycin SCHEMBL8221756 1.00 CTSL (1.00) CTSLDRD1PTGS1PDE4AF2
Daptomycin SCHEMBL8221760 1.00 CTSL (1.00) CTSLDRD1PTGS1PDE4AF2
Daptomycin SCHEMBL2724847 1.00 CTSL (1.00) CTSLDRD1PTGS1PDE4AF2
Daptomycin SCHEMBL16274142 1.00 CTSL (1.00) CTSLDRD1PTGS1PDE4AF2
Daptomycin SCHEMBL23046993 1.00 CTSL (1.00) CTSLDRD1PTGS1PDE4AF2
Daptomycin SCHEMBL13491700 1.00 CTSL (1.00) CTSLDRD1PTGS1PDE4AF2
Daptomycin SCHEMBL21402170 1.00 CTSL (1.00) CTSLDRD1PTGS1PDE4AF2
Daptomycin SCHEMBL8227262 1.00 CTSL (1.00) CTSLDRD1PTGS1PDE4AF2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 50 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4724107-A2 OPHTHALMIC FILMS Fount Bio, Inc. (US) 2026-04-15 — — EP disclosed
CN-119874830-A Preparation method of daptomycin stable crystal form 南京工业大学 2025-04-25 — — CN disclosed
WO-2024254278-A9 OPHTHALMIC FILMS FOUNT BIO, INC. (US) 2025-02-13 — — WO disclosed
WO-2024254278-A2 OPHTHALMIC FILMS FOUNT BIO, INC. (US) 2024-12-12 — — WO disclosed
CN-113710225-B Delivery and retention of active agents within the skin 范德生物公司 2024-06-21 — — CN disclosed
CN-113943710-B Culture medium for CAR-T cell culture and application thereof 浙江大学医学院附属第一医院 2023-03-24 — — CN disclosed
CN-108350030-B Skin permeable peptides and methods of use thereof 汉阳大学校产学协力团 2022-12-13 — — CN disclosed
EP-3641753-B1 BACITRACIN AND/OR DAPTOMYCIN COMBINED WITH CANNABIDIOL FOR TREATMENT OF BACTERIAL INFECTIONS UNIV SYDDANSK (DK) 2022-09-21 — — EP disclosed
CN-114814046-B Method for rapidly detecting daptomycin in meat food and application 南京市食品药品监督检验院 2022-09-16 — — CN disclosed
CN-114814046-A Method for rapidly detecting daptomycin in meat food and application 南京市食品药品监督检验院 2022-07-29 — — CN disclosed
WO-2016033314-A1 SKIN PENETRATING PEPTIDES (SPPS) AND METHODS OF USE THEREFOR THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2016-03-03 — — WO disclosed
US-20150366985-A1 ANTI-WALL TEICHOIC ANTIBODIES AND CONJUGATES GENENTECH, INC. (US) 2015-12-24 — — US disclosed
US-20140227174-A1 SKIN PERMEATING AND CELL ENTERING (SPACE) PEPTIDES AND METHODS OF USE THEREFOR THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2014-08-14 — — US disclosed
US-20140161871-A1 SKIN PERMEATING AND CELL ENTERING (SPACE) PEPTIDES AND METHODS OF USE THEREOF THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2014-06-12 — — US disclosed
EP-2638162-A2 SKIN PERMEATING AND CELL ENTERING (SPACE) PEPTIDES AND METHODS OF USE THEREOF The Regents of the University of California (US) 2013-09-18 — — EP disclosed
US-8518871-B2 Skin permeating and cell entering (SPACE) peptides and methods of use thereof THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2013-08-27 — — US disclosed
CN-103201386-A Skin penetrating and cell entering (SPACE) peptides and methods of use thereof UNIV CALIFORNIA 2013-07-10 — — CN disclosed
WO-2012064429-A2 SKIN PERMEATING AND CELL ENTERING (SPACE) PEPTIDES AND METHODS OF USE THEREOF THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2012-05-18 — — WO disclosed
US-7927613-B2 Pharmaceutical co-crystal compositions UNIVERSITY OF SOUTH FLORIDA (US) 2011-04-19 — — US disclosed
US-7790905-B2 Pharmaceutical propylene glycol solvate compositions MCNEIL-PPC, INC. (US) 2010-09-07 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150366985-A1 ANTI-WALL TEICHOIC ANTIBODIES AND CONJUGATES STT3A, STT3B, DDOST CTSL 2518/4885DRD1 3783/4885PTGS1 3631/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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