Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | TPMT | P51580 | 1/20 | 0.38 |
| ▸ | F2 | P00734 | 2/20 | 0.37 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.37 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.37 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | GPR17 | Q13304 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL111999 | 0.86 | HRH3 (0.40) | LMNAKDM4EMAPTALDH1A1GAA | |
| Hydrochloric Acid SCHEMBL7894748 | 0.84 | LMNA (0.42) | LMNAKDM4EMAPTALDH1A1GAA | |
| Carbamic Acid SCHEMBL28131089 | 0.78 | TPMT (0.57) | KDM4EMAPTTPMTPRSS1PRSS2 | |
| Carbamic Acid SCHEMBL28520575 | 0.78 | BCL2 (0.44) | LMNAKDM4EMAPTPOLBTPMT | |
| Carbamic Acid SCHEMBL28472409 | 0.76 | NQO1 (0.42) | LMNAKDM4EMAPTPOLBTPMT | |
| SCHEMBL5739986 | 0.76 | SELL (0.44) | LMNAKDM4EMAPTPOLBALDH1A1 | |
| SCHEMBL777612 | 0.76 | HTT (0.45) | LMNAKDM4EMAPTPOLBTPMT | |
| Carbamic Acid SCHEMBL28155281 | 0.75 | TPMT (0.60) | KDM4ETPMTPRSS1PRSS2PRSS3 | |
| SCHEMBL27843664 | 0.74 | KDM4E (0.53) | LMNAKDM4ETPMTALDH1A1TSHR | |
| SCHEMBL6017716 | 0.74 | GPR17 (0.41) | LMNAKDM4EMAPTF2PRSS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109265400-A | Arginine methyltransferase inhibitor and application thereof | EPIZYME股份有限公司 | 2019-01-25 | — | — | CN | disclosed |
| CN-105339351-B | Arginine methyltransferase inhibitors and uses thereof | EPIZYME股份有限公司 | 2018-11-06 | — | — | CN | disclosed |
| CN-105228997-B | Carm1 inhibitors and uses thereof | EPIZYME股份有限公司 | 2018-03-27 | — | — | CN | disclosed |
| CN-105452226-B | Tetrahydro-and dihydro-isoquinoline PRMT5 inhibitors and uses thereof | EPIZYME股份有限公司 | 2017-09-12 | — | — | CN | disclosed |
| CN-106029653-A | Diaminopyrimidine benzenesulfone derivatives and uses thereof | 达纳-法伯癌症研究所股份有限公司 | 2016-10-12 | — | — | CN | disclosed |