Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR17 | Q13304 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.37 |
| ▸ | F2 | P00734 | 1/20 | 0.37 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.37 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.37 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.37 |
| ▸ | HTR1D | P28221 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30946559 | 0.85 | CYP3A4 (0.39) | IDO1NPSR1CAPN1HTR1DHTT | |
| SCHEMBL11392001 | 0.84 | GPR17 (0.42) | GPR17HRH3LMNAKDM4ENPSR1 | |
| SCHEMBL24747566 | 0.83 | NPC1 (0.39) | GPR17LMNAKDM4ENPSR1ALDH1A1 | |
| SCHEMBL14988768 | 0.83 | NPSR1 (0.57) | GPR17HRH3KDM4ENPSR1MAPT | |
| SCHEMBL27964907 | 0.83 | CAPN1 (0.46) | LMNACAPN1PRSS1PRSS2PRSS3 | |
| SCHEMBL11099663 | 0.83 | KDM4E (0.44) | GPR17HRH3LMNAKDM4ENPSR1 | |
| SCHEMBL19594797 | 0.81 | HRH3 (0.40) | GPR17HRH3LMNAKDM4EF2 | |
| SCHEMBL777612 | 0.80 | HTT (0.45) | GPR17LMNAKDM4EF2PRSS1 | |
| SCHEMBL7193838 | 0.79 | ALDH1A1 (0.42) | GPR17HRH3LMNAKDM4ENPSR1 | |
| SCHEMBL14988847 | 0.79 | LMNA (0.39) | GPR17HRH3LMNAHTR1DGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1708992-A1 | SULFONAMIDE DERIVATIVES FOR THE TREATMENT OF DISEASES | Pfizer Limited (GB) | 2006-10-11 | — | — | EP | claimed |
| WO-2005080324-A1 | SULFONAMIDE DERIVATIVES FOR THE TREATMENT OF DISEASES | PFIZER LIMITED (GB) | 2005-09-01 | — | — | WO | claimed |
| CN-114728906-A | Novel chemical method for preparing key intermediate 6-chloro-4- (4-fluoro-2-methylphenyl) pyridine-3-amine of NT-814 | 康堤医疗有限公司 | 2022-07-08 | — | — | CN | disclosed |
| EP-1708992-A1 | SULFONAMIDE DERIVATIVES FOR THE TREATMENT OF DISEASES | Pfizer Limited (GB) | 2006-10-11 | — | — | EP | disclosed |
| WO-2005080324-A1 | SULFONAMIDE DERIVATIVES FOR THE TREATMENT OF DISEASES | PFIZER LIMITED (GB) | 2005-09-01 | — | — | WO | disclosed |