Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | LDHA | P00338 | 1/20 | 0.30 |
| ▸ | LDHB | P07195 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL164413 | 0.97 | — | — | |
| SCHEMBL31474683 | 0.94 | ACHE (0.33) | ACHEPOLBCYP3A4PARP1MAPT | |
| Iodide SCHEMBL9871002 | 0.94 | ACHE (0.33) | ACHEPOLBCYP3A4PARP1MAPT | |
| SCHEMBL11166985 | 0.94 | ACHE (0.33) | ACHEPOLBCYP3A4PARP1MAPT | |
| SCHEMBL15636686 | 0.81 | ACHE (0.32) | ACHE | |
| Hydrochloric Acid SCHEMBL8068553 | 0.75 | KMT2A (0.36) | ACHEPOLBMAPTL3MBTL1 | |
| SCHEMBL8949617 | 0.72 | — | — | |
| Hydrochloric Acid SCHEMBL9249515 | 0.72 | F7 (0.32) | — | |
| SCHEMBL313063 | 0.71 | — | — | |
| SCHEMBL11047060 | 0.71 | KMT2A (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200046741-A1 | SMALL MOLECULE CD38 INHIBITORS AND METHODS OF USING SAME | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH | 2020-02-13 | — | — | US | disclosed |
| US-20100236936-A1 | Aqueous,alkaline,cyanide-free bath for the galvanic deposition of zinc and zinc alloy coatings | ATOTECH DEUTSCHLAND GMBH (DE) | 2010-09-23 | — | — | US | disclosed |
| US-20100155257-A1 | Aqueous, alkaline, cyanide-free bath for the galvanic deposition of zinc alloy coatings | ATOTECH DEUTSCHLAND GMBH (DE) | 2010-06-24 | — | — | US | disclosed |
| US-5601971-A | HIGH STRENGTH, WATERPROOF; CONTAINING AN IMIDAZOLIUM AND A S-TRIAZINE COMPOUND | STERLING DIAGNSOTIC IMAGING, INC. (US) | 1997-02-11 | — | — | US | disclosed |
| EP-0247482-B1 | HARDENED REAGENT COATINGS, AND PROCESSES FOR THE PREPARATION THEREOF | MILES INC. (US) | 1992-04-22 | — | — | EP | disclosed |
| EP-0247482-A2 | Hardened reagent coatings, and processes for the preparation thereof | MILES INC. (US) | 1987-12-02 | — | — | EP | disclosed |
| EP-0212340-A1 | 2-(heteroalkyl)-1,4-dihydropyridines, process for their preparations and pharmaceutical compositions containing them | BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) | 1987-03-04 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200046741-A1 | SMALL MOLECULE CD38 INHIBITORS AND METHODS OF USING SAME | CD38, BCL6B, DNASE1L3 | ACHE 4454/4885POLB 1331/4885CYP3A4 4721/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.