Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 | P11387 | 4/20 | 0.57 |
| ▸ | ACACA | Q13085 | 3/20 | 0.49 |
| ▸ | ESR1 | P03372 | 1/20 | 0.47 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.46 |
| ▸ | MET | P08581 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | METAP2 | P50579 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.44 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | ACP1 | P24666 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28118653 | 0.89 | TOP1 (0.58) | TOP1ACACAESR1NPBWR1KDM4E | |
| SCHEMBL25171878 | 0.88 | TOP1 (0.68) | TOP1ACACAKDM4EMAPK1ALDH1A1 | |
| SCHEMBL28046863 | 0.85 | ESR1 (0.45) | TOP1ESR1NPBWR1METKDM4E | |
| SCHEMBL22983973 | 0.85 | ACHE (0.64) | TOP1ESR1NPBWR1METKDM4E | |
| SCHEMBL5931070 | 0.81 | TOP1 (0.60) | TOP1ACACAMETKDM4EMAPK1 | |
| SCHEMBL13458752 | 0.80 | TOP1 (0.59) | TOP1ACACAMETKDM4EMAPT | |
| SCHEMBL28170035 | 0.78 | GRM4 (0.67) | TOP1NPBWR1METGRM4KIF11 | |
| SCHEMBL1042853 | 0.77 | ACACA (0.72) | TOP1ACACAKDM4EMAPK1ALDH1A1 | |
| SCHEMBL29399315 | 0.77 | ACACA (0.72) | TOP1ACACAKDM4EMAPK1ALDH1A1 | |
| SCHEMBL5931163 | 0.77 | TOP1 (0.49) | TOP1METAP2KCNH2HPGDTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106366035-B | Synthesis method of quinoline derivative | 南阳师范学院 | 2021-05-07 | — | — | CN | disclosed |
| CN-106380463-B | Method for synthesizing quinoline derivative | 南阳师范学院 | 2020-12-15 | — | — | CN | disclosed |
| CN-105175328-B | It is a kind of using aromatic amine, aromatic aldehyde, ketone synthesis of quinoline derivatives method | 南阳师范学院 | 2017-12-19 | — | — | CN | disclosed |
| CN-106380463-A | Method for synthesis of quinoline derivatives | 南阳师范学院 | 2017-02-08 | — | — | CN | disclosed |
| CN-106366035-A | Method for synthesizing quinoline derivative | 南阳师范学院 | 2017-02-01 | — | — | CN | disclosed |