Silafluofen

Silafluofen

SCHEMBL28105102

CCOc1ccc([Si](C)(C)CCCc2ccc(F)c(Oc3ccccc3)c2)cc1.COP(=O)(OC)OC=C(Cl)Cl

nearest known ligand 0.33

Full drug profile on Sugi Atlas →

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
TP53 P04637 3/20 0.33
MAPT P10636 7/20 0.32
GAA P10253 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.32
LMNA P02545 2/20 0.31
ALDH1A1 P00352 2/20 0.31
CYP3A4 P08684 1/20 0.31
ALOX15 P16050 1/20 0.31
TSHR P16473 1/20 0.31
ACHE P22303 1/20 0.31
LPAR1 Q92633 2/20 0.31
LPAR5 Q9H1C0 2/20 0.31
S1PR3 Q99500 1/20 0.31
LTA4H P09960 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Silafluofen SCHEMBL8880052 0.85 LTA4H (0.43) MAPTGAALMNAALDH1A1LPAR1
Silafluofen SCHEMBL27295 0.85 LTA4H (0.43) MAPTGAALMNAALDH1A1LPAR1
Silafluofen SCHEMBL7861197 0.82 KMT2A (0.38) MAPTSMN1; SMN2LPAR1LPAR5LTA4H
Silafluofen SCHEMBL1161109 0.79 LTA4H (0.37) MAPTLMNALTA4H
SCHEMBL10489498 0.77 LPAR1 (0.42) SMN1; SMN2ALDH1A1ALOX15LPAR1LPAR5
SCHEMBL8915494 0.75 LTA4H (0.40) MAPTGAALMNAALDH1A1LPAR1
Silafluofen SCHEMBL15019112 0.72 LTA4H (0.33) MAPTLTA4H
SCHEMBL12711013 0.72 LPAR1 (0.33) LPAR1LPAR5
Silafluofen SCHEMBL2400888 0.71 TDP1 (0.53) LMNAALDH1A1
Silafluofen SCHEMBL21468772 0.71 TDP1 (0.55) TP53MAPTLMNAALDH1A1CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-106163274-A Aerosol for mosquito control and method for mosquito control 大日本除虫菊株式会社 2016-11-23 CN disclosed
CN-106028806-A Aerosol for mosquito control and method for mosquito control 大日本除虫菊株式会社 2016-10-12 CN disclosed