Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.53 |
| ▸ | GFER | P55789 | 1/20 | 0.53 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.53 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 4/20 | 0.51 |
| ▸ | RAB9A | P51151 | 4/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | HTR3A | P46098 | 1/20 | 0.47 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28304654 | 0.87 | L3MBTL1 (0.62) | GAAALDH1A1KMT2AMAPTKDM4E | |
| Hydrochloric Acid SCHEMBL10436132 | 0.85 | L3MBTL1 (0.60) | GAAALDH1A1KMT2AMAPTKDM4E | |
| SCHEMBL9937342 | 0.85 | GAA (0.57) | GAANPSR1ALDH1A1KMT2AMAPT | |
| SCHEMBL28923975 | 0.85 | MAPT (0.55) | GAANPSR1ALDH1A1KMT2AMAPT | |
| SCHEMBL8542788 | 0.84 | ALDH1A1 (0.47) | GAANPSR1ALDH1A1KMT2AMAPT | |
| SCHEMBL20640028 | 0.83 | MAPT (0.50) | GAANPSR1ALDH1A1KMT2AMAPT | |
| SCHEMBL28096400 | 0.83 | ALDH1A1 (0.50) | GAANPSR1ALDH1A1KMT2AMAPT | |
| SCHEMBL3914229 | 0.81 | AKR1C3 (0.51) | GAAALDH1A1KMT2AMAPTKDM4E | |
| SCHEMBL21590319 | 0.81 | GAA (0.53) | GAANPSR1ALDH1A1KMT2AMAPT | |
| SCHEMBL29771394 | 0.81 | GFER (0.51) | GAANPSR1ALDH1A1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106103445-B | The therapeutical uses of pyrazolo [1,5-A] pyrimidine -5,7- diamine compound and they as CDK inhibitor | 癌症研究技术有限公司 | 2019-08-09 | — | — | CN | disclosed |
| CN-106103445-A | Pyrazolo [1,5 A] pyrimidine 5,7 diamine compound and their therapeutic use as CDK inhibitor | 癌症研究技术有限公司 | 2016-11-09 | — | — | CN | disclosed |