SCHEMBL28111426

SCHEMBL28111426

C[CH]C(=O)c1ccc(OC)cc1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CES2 O00748 2/20 0.61
CES1 P23141 2/20 0.61
F3 P13726 2/20 0.61
MAPT P10636 4/20 0.59
ALDH1A1 P00352 3/20 0.59
HPGD P15428 1/20 0.59
CA1 P00915 5/20 0.59
CA2 P00918 5/20 0.59
CYP1A2 P05177 1/20 0.58
CYP3A4 P08684 1/20 0.58
CYP2C19 P33261 1/20 0.58
PARP1 P09874 1/20 0.57
PARP10 Q53GL7 1/20 0.57
PARP2 Q9UGN5 1/20 0.57
PARP4 Q9UKK3 1/20 0.57
MEN1 O00255 2/20 0.56
MAOB P27338 2/20 0.56
KMT2A Q03164 2/20 0.56
HSPD1 P10809 1/20 0.56
TNFRSF1A P19438 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7000262 0.84 F3 (0.75) CES2CES1F3MAPTALDH1A1
SCHEMBL7000261 0.84 F3 (0.75) CES2CES1F3MAPTALDH1A1
SCHEMBL5468041 0.83 F3 (0.68) CES2CES1F3MAPTALDH1A1
SCHEMBL11807743 0.83 F3 (0.68) CES2CES1F3MAPTALDH1A1
SCHEMBL5468035 0.83 F3 (0.68) CES2CES1F3MAPTALDH1A1
SCHEMBL1641142 0.83 CES2 (0.61) CES2CES1F3MAPTALDH1A1
SCHEMBL3983289 0.81 F3 (0.59) CES2CES1F3MAPTALDH1A1
SCHEMBL546672 0.81 F3 (0.59) CES2CES1F3MAPTALDH1A1
Water SCHEMBL3047437 0.81 F3 (0.59) CES2CES1F3MAPTALDH1A1
SCHEMBL19309804 0.81 F3 (0.59) CES2CES1F3MAPTALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-106242968-B By α, method that β unsaturated carboxylic acids and ketone compounds directly synthesize the alpha-acyloxy ketone derivatives containing ethylenic unsaturation 沅江华龙催化科技有限公司 2018-11-06 CN disclosed
CN-106220495-B The method that the alpha-acyloxy ketone derivatives containing ethylenic unsaturation are directly synthesized by α-reaction kinetic of ketone 沅江华龙催化科技有限公司 2018-10-26 CN disclosed
CN-106220496-B By α, method that β unsaturated carboxylic acids and phenylpropyl alcohol ketone class compound directly synthesize the alpha-acyloxy ketone derivatives containing ethylenic unsaturation 沅江华龙催化科技有限公司 2018-10-26 CN disclosed
CN-106242968-A The method being directly synthesized α acyloxy ketone derivatives containing ethylenic unsaturation by α, β unsaturated carboxylic acid and ketone compounds 沅江华龙催化科技有限公司 2016-12-21 CN disclosed
CN-106220495-A The method being directly synthesized α acyloxy ketone derivatives containing ethylenic unsaturation by the α reaction kinetic of ketone 沅江华龙催化科技有限公司 2016-12-14 CN disclosed
CN-106220496-A The method being directly synthesized α acyloxy ketone derivatives containing ethylenic unsaturation by α, β unsaturated carboxylic acid and propiophenone compounds 沅江华龙催化科技有限公司 2016-12-14 CN disclosed