Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.32 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.32 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.32 |
| ▸ | TTK | P33981 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | AXL | P30530 | 1/20 | 0.31 |
| ▸ | CDK8 | P49336 | 1/20 | 0.31 |
| ▸ | APP | P05067 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25934515 | 0.73 | MAPK1 (0.50) | MAPK1KDM4EALDH1A1GAAMAPT | |
| SCHEMBL28111579 | 0.69 | TTK (0.39) | MAPK8TTKJAK2CDK8 | |
| SCHEMBL977078 | 0.66 | CSNK1A1 (0.48) | MAPK1 | |
| SCHEMBL29870187 | 0.66 | CSNK1A1 (0.48) | MAPK1 | |
| SCHEMBL4559275 | 0.66 | MAPT (0.52) | MAPK1KDM4EALDH1A1GAAMAPT | |
| SCHEMBL14104385 | 0.65 | MAPK1 (0.41) | MAPK1AXL | |
| SCHEMBL25934516 | 0.64 | MAPK1 (0.44) | MAPK1 | |
| SCHEMBL16415962 | 0.62 | HTR6 (0.53) | MAPK1KDM4EALDH1A1GAAMAPT | |
| SCHEMBL20209150 | 0.62 | MAPK1 (0.40) | MAPK1 | |
| SCHEMBL20208921 | 0.62 | ALDH1A1 (0.41) | MAPK1ALDH1A1MAPTJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106061973-A | Pyrrolo [2,3-D ] pyrimidinyl, pyrrolo [2,3-B ] pyrazinyl and pyrrolo [2,3-D ] pyridylacrylamide | 辉瑞公司 | 2016-10-26 | — | — | CN | disclosed |