Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 7/20 | 0.52 |
| ▸ | CHUK | O15111 | 6/20 | 0.52 |
| ▸ | PRKCI | P41743 | 3/20 | 0.50 |
| ▸ | AXL | P30530 | 1/20 | 0.50 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.45 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.45 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.45 |
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.45 |
| ▸ | PAK4 | O96013 | 1/20 | 0.45 |
| ▸ | CSF1R | P07333 | 1/20 | 0.45 |
| ▸ | RET | P07949 | 1/20 | 0.45 |
| ▸ | IGF1R | P08069 | 1/20 | 0.45 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.45 |
| ▸ | PRKACA | P17612 | 1/20 | 0.45 |
| ▸ | FLT1 | P17948 | 1/20 | 0.45 |
| ▸ | LTK | P29376 | 1/20 | 0.45 |
| ▸ | GRK5 | P34947 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12605441 | 0.83 | TNNI3K (0.53) | IKBKBCHUKPRKCIAXLROCK1 | |
| SCHEMBL1075569 | 0.82 | IKBKB (0.59) | IKBKBCHUKPRKCIAXLROCK1 | |
| SCHEMBL1036770 | 0.82 | PRKCI (0.55) | IKBKBCHUKPRKCIAXLROCK1 | |
| SCHEMBL28111978 | 0.78 | IKBKB (0.48) | IKBKBCHUKPRKCIAXLROCK1 | |
| SCHEMBL5137242 | 0.77 | MET (0.64) | IKBKBCHUKPRKCIAXLROCK1 | |
| SCHEMBL7028646 | 0.75 | IKBKB (0.49) | IKBKBCHUKPRKCIAXLROCK1 | |
| SCHEMBL4792437 | 0.74 | IKBKB (0.74) | IKBKBCHUKROCK1PTK2DAPK3 | |
| SCHEMBL3093132 | 0.72 | PRKCI (0.55) | IKBKBCHUKPRKCIAXLROCK1 | |
| SCHEMBL1701327 | 0.71 | ADRA1A (0.34) | IKBKBCHUKALK | |
| SCHEMBL91443 | 0.71 | PRKCI (0.59) | IKBKBCHUKPRKCIAXLROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104854108-A | Pyrrolotriazinone derivatives as pi3k inhibitors | ALMIRALL SA | 2015-08-19 | — | — | CN | disclosed |