Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 5/20 | 0.56 |
| ▸ | CYP2A6 | P11509 | 3/20 | 0.56 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.39 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.39 |
| ▸ | DRD2 | P14416 | 2/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | MLNR | O43193 | 1/20 | 0.39 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.39 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.39 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.39 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30735587 | 0.87 | HTR6 (0.54) | CYP1A2CYP2A6SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL19284659 | 0.87 | HTR6 (0.54) | CYP1A2CYP2A6SLC6A4SLC6A2SLC6A3 | |
| Hydrochloric Acid SCHEMBL19284709 | 0.85 | HTR2C (0.53) | CYP1A2CYP2A6SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL19297018 | 0.79 | CYP1A2 (0.46) | CYP1A2CYP2A6NR4A2KMT2AMEN1 | |
| SCHEMBL29209718 | 0.79 | ACHE (0.41) | CYP1A2NR4A2KMT2AMEN1CYP3A4 | |
| SCHEMBL22953975 | 0.77 | CYP1A2 (0.41) | CYP1A2CYP2A6NR4A2KMT2ACYP3A4 | |
| SCHEMBL29494605 | 0.75 | CYP2A6 (1.00) | CYP1A2CYP2A6NR4A2KMT2AMEN1 | |
| SCHEMBL2473555 | 0.75 | CYP2A6 (1.00) | CYP1A2CYP2A6NR4A2KMT2AMEN1 | |
| SCHEMBL29261846 | 0.75 | CYP2A6 (0.52) | CYP1A2CYP2A6NR4A2KMT2ANPC1 | |
| SCHEMBL19942354 | 0.74 | HTR6 (0.38) | CYP1A2CYP3A4SLC6A4DRD2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106187927-A | A kind of preparation method of Lesinurad intermediate | 山东川成医药股份有限公司 | 2016-12-07 | — | — | CN | claimed |
| CN-106187927-B | Preparation method of Lesinurad intermediate | 山东川成医药股份有限公司 | 2020-02-04 | — | — | CN | disclosed |
| CN-106187927-B | Preparation method of Lesinurad intermediate | 山东川成医药股份有限公司 | 2020-02-04 | — | — | CN | disclosed |
| CN-106187927-A | A kind of preparation method of Lesinurad intermediate | 山东川成医药股份有限公司 | 2016-12-07 | — | — | CN | disclosed |