Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 2/20 | 0.33 |
| ▸ | METAP1 | P53582 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.37 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | PGR | P06401 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18261221 | 0.82 | METAP1 (0.46) | METAP1MAPTMEN1KMT2APARP10 | |
| Hydrochloric Acid SCHEMBL3273192 | 0.79 | METAP1 (0.41) | METAP1MAPTMEN1KMT2APARP10 | |
| SCHEMBL28265785 | 0.77 | METAP1 (0.42) | METAP1MAPTMEN1KMT2APARP10 | |
| SCHEMBL27845467 | 0.77 | METAP1 (0.42) | METAP1MAPTMEN1KMT2APARP10 | |
| SCHEMBL25878365 | 0.77 | METAP1 (0.42) | METAP1MAPTMEN1KMT2APARP10 | |
| SCHEMBL5684541 | 0.77 | METAP1 (0.42) | METAP1MAPTMEN1KMT2APARP10 | |
| SCHEMBL8917219 | 0.76 | METAP1 (0.41) | METAP1MAPTMEN1KMT2APARP10 | |
| Hydrochloric Acid SCHEMBL8428997 | 0.76 | METAP1 (0.41) | METAP1MAPTMEN1KMT2APARP10 | |
| SCHEMBL6903249 | 0.76 | METAP1 (0.41) | METAP1MAPTMEN1KMT2APARP10 | |
| SCHEMBL601330 | 0.75 | MAPT (0.45) | METAP1MAPTMEN1KMT2APARP10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106068291-B | Olefin-based resin, its manufacturing method and propylene resin composition | 三井化学株式会社 | 2019-03-12 | — | — | CN | disclosed |
| CN-106068291-A | Olefin-based resin, its manufacture method and propylene resin composition | 三井化学株式会社 | 2016-11-02 | — | — | CN | disclosed |