Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.46 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | HBB | P68871 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | DHFR | P00374 | 1/20 | 0.30 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.30 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13063787 | 0.72 | TP53 (0.37) | CYP1A2CYP3A4CYP2D6TSHRNFKB1 | |
| SCHEMBL4846610 | 0.72 | TP53 (0.37) | CYP1A2CYP3A4CYP2D6TSHRNFKB1 | |
| SCHEMBL8897393 | 0.70 | KMT2A (0.47) | CYP3A4CYP2D6CYP2C19MEN1KMT2A | |
| SCHEMBL1614716 | 0.70 | KMT2A (0.47) | CYP3A4CYP2D6CYP2C19MEN1KMT2A | |
| SCHEMBL8855488 | 0.70 | KMT2A (0.47) | CYP3A4CYP2D6CYP2C19MEN1KMT2A | |
| SCHEMBL23458283 | 0.70 | FGFR1 (0.35) | TP53HBBSMN1; SMN2GRIN2BBRD4 | |
| SCHEMBL27474143 | 0.69 | GRIN2B (0.45) | CYP1A2CYP3A4CYP2D6TSHRNFKB1 | |
| SCHEMBL18546641 | 0.64 | TP53 (0.35) | TP53HBBSMN1; SMN2MAPTDHFR | |
| SCHEMBL5655701 | 0.62 | KCNH2 (0.40) | BRD4 | |
| SCHEMBL27292735 | 0.59 | FGFR1 (0.69) | TP53HBBSMN1; SMN2GRIN2BMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107266681-A | Amine polymer as bile acid sequestrant | 瑞立普萨公司 | 2017-10-20 | — | — | CN | disclosed |
| CN-102906159-B | Amine polymers as bile acid sequestrants | 瑞立普萨公司 | 2017-09-26 | — | — | CN | disclosed |
| CN-106478948-A | Polyimidazole as bile acid sequestrant | 瑞立普萨公司 | 2017-03-08 | — | — | CN | disclosed |
| CN-102858347-B | Polyimidazoles as bile acid sequestrants | 瑞立普萨公司 | 2016-11-02 | — | — | CN | disclosed |