SCHEMBL28113838

SCHEMBL28113838

O=C=Nc1ccc(F)c(C(F)(F)F)c1.O=C=Nc1ccc(F)cc1C(F)(F)F.O=C=Nc1ccccc1

nearest known ligand 0.35

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
TRPA1 O75762 1/20 0.35
CYP3A4 P08684 1/20 0.35
SLC22A12 Q96S37 1/20 0.32
MAPK1 P28482 1/20 0.31
TDP1 Q9NUW8 1/20 0.31
GRM4 Q14833 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29648906 0.81 MAPK1 (0.44) TRPA1CYP3A4SLC22A12MAPK1TDP1
SCHEMBL30438763 0.81 IDO1 (0.39) TRPA1CYP3A4TDP1
SCHEMBL424482 0.81 IDO1 (0.39) TRPA1CYP3A4TDP1
SCHEMBL60206 0.81 MAPK1 (0.44) TRPA1CYP3A4SLC22A12MAPK1TDP1
SCHEMBL3104369 0.81 CYP3A4 (0.50) TRPA1CYP3A4MAPK1TDP1
SCHEMBL13219987 0.72 CYP3A4 (0.40) TRPA1CYP3A4MAPK1TDP1
SCHEMBL8593598 0.72 MAPK1 (0.47) TRPA1CYP3A4MAPK1TDP1
SCHEMBL6895856 0.69 ALDH1A1 (0.43) TRPA1CYP3A4MAPK1TDP1
SCHEMBL8942928 0.69 NPC1 (0.45) TRPA1CYP3A4MAPK1TDP1
SCHEMBL1493109 0.69 CYP3A4 (0.55) TRPA1CYP3A4MAPK1TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-106232666-A Post-modification polycarbodiimide 巴斯夫欧洲公司 2016-12-14 CN disclosed