SCHEMBL30438763

SCHEMBL30438763

O=C=Nc1ccc(F)cc1C(F)(F)F

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
IDO1 P14902 2/20 0.39
CYP3A4 P08684 3/20 0.36
ALDH1A1 P00352 2/20 0.36
HPGD P15428 1/20 0.36
TDP1 Q9NUW8 1/20 0.36
TRPA1 O75762 2/20 0.34
HCAR1 Q9BXC0 1/20 0.33
KMT2A Q03164 2/20 0.32
KDM4E B2RXH2 1/20 0.32
GAA P10253 1/20 0.32
MAPT P10636 1/20 0.32
HTT P42858 1/20 0.32
MRGPRX4 Q96LA9 1/20 0.31
AR P10275 1/20 0.31
SLC6A2 P23975 4/20 0.31
SLC6A4 P31645 4/20 0.31
ATM Q13315 1/20 0.31
HDAC3 O15379 1/20 0.31
HDAC1 Q13547 1/20 0.31
HDAC2 Q92769 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL424482 1.00 IDO1 (0.39) IDO1CYP3A4ALDH1A1HPGDTDP1
SCHEMBL9235250 0.83 CYP3A4 (0.49) CYP3A4ALDH1A1HPGDTDP1TRPA1
SCHEMBL28591458 0.81 IDO1 (0.39) IDO1CYP3A4ALDH1A1HPGDTDP1
SCHEMBL3104369 0.81 CYP3A4 (0.50) CYP3A4ALDH1A1HPGDTDP1TRPA1
SCHEMBL31135862 0.81 CES2 (0.46) CYP3A4ALDH1A1HPGDTDP1TRPA1
SCHEMBL10905501 0.81 CES2 (0.46) CYP3A4ALDH1A1HPGDTDP1TRPA1
SCHEMBL28113838 0.81 TRPA1 (0.35) CYP3A4TDP1TRPA1
SCHEMBL1783029 0.80 CYP3A4 (0.41) CYP3A4ALDH1A1HPGDTDP1TRPA1
SCHEMBL162277 0.80 RAB9A (0.40) CYP3A4ALDH1A1HPGDTDP1TRPA1
SCHEMBL29648862 0.80 RAB9A (0.40) CYP3A4ALDH1A1HPGDTDP1TRPA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-112020525-B Adducts of amine catalysts for preparing isocyanurate polymers 科思创知识产权两合公司 2023-05-16 CN disclosed